Search for dissertations about: "on anti arthritis activity"

Showing result 21 - 25 of 85 swedish dissertations containing the words on anti arthritis activity.

  2. 21. Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment

    Author : Karina Roxana Gheorghe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss of function. This condition affects 0. READ MORE

  4. 22. Cyclic peptides as biological tools : Applications for diagnosis and therapeutics in rheumatoid arthritis and COVID-19

    Author : Camilla Eriksson; Ulf Göransson; Sunithi Gunasekera; Christian Becker; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Scaffold peptides; peptide grafting; rheumatoid arthritis; SARS-CoV-2; autoantibodies; peptide synthesis; pharmacognosy;

    Abstract : The overall aims of the projects included in this thesis were to design, synthesize and evaluate cyclic peptide scaffolds grafted with biological epitopes for their ability to bind antibodies in rheumatoid arthritis and COVID-19 sera. One of the main outcomes of this thesis was the observation that scaffold peptides grafted with target epitopes efficiently neutralized anti-citrullinated protein autoantibodies (ACPA) from rheumatoid arthritis patients. READ MORE

  5. 23. Molecular studies on the autoantibody-mediated bone destruction in rheumatoid arthritis

    Author : Akilan Krishnamurthy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoantibody-positive rheumatoid arthritis (RA), also called seropositive RA, is characterised by the presence of anti citrullinated proteins antibodies (ACPA) that can be detected in blood several years before disease onset. Joint inflammation, pain and bone destruction are major features of the disease. READ MORE

  6. 24. Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis

    Author : Omar M. Khan; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GGTase-I; Inflammation; RHO proteins; Rheumatoid Arthritis; Atherosclerosis;

    Abstract : RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including cancer and inflammation. READ MORE

  7. 25. The role of anti-collagen type II antibodies in the pathogenesis and prognosis of rheumatoid arthritis

    Author : Vivek Anand Manivel; Johan Rönnelid; Arne Egesten; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; Anti-collagen type II antibodies; HLADRB1*; Granulocytes; prognosis; ;

    Abstract : Rheumatoid arthritis (RA) which affects 0.5-1% of the world population and is characterised by joint erosions and presence of the autoantibodies anti-citrullinated protein antibodies (ACPA) and rheumatoid factor. READ MORE