Search for dissertations about: "on antibiotics"

Showing result 1 - 5 of 457 swedish dissertations containing the words on antibiotics.

  2. 1. Molecular Interplay of Antibiotics on the Bacterial Ribosome

    Author : Narayan Prasad Parajuli; Suparna Sanyal; Michael Y. Pavlov; Chandra Sekhar Mandava; Axel Innis; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Translation; Antibiotics; Aminoglycoside; Thermorubin; Protein synthesis; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. READ MORE

  4. 2. Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs

    Author : Anna Nyhlén; Sektion III; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotics; neutropenic; antineoplastic agents; pharmacokinetics; pharmacodynamics; PAE; interactions; synergy; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; mykologi; virologi;

    Abstract : The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on the intestinal microflora. READ MORE

  5. 3. Unpacking Rational Use of Antibiotics : Policy in Medical Practice and the Medical Debate

    Author : Hedvig Gröndal; Tora Holmberg; Ericka Johnson; Uppsala universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Antibiotics; Policy; Medical Sociology; Actor-Network Theory; Human-microbial relations; Antimicrobial Resistance; Everyday Infections; Material semiotics; Medical sociology; Medical objects; Medical technologies; Medical knowledge; Sociologi; Sociology;

    Abstract : Rational use of antibiotics–using antibiotics only when needed and in the right way–is a prioritized goal in policy aimed at preventing antimicrobial resistance. A vast body of research is devoted to understanding why unnecessary antibiotics are prescribed. READ MORE

  6. 4. A tale of two antibiotics : Fusidic acid and Viomycin

    Author : Mikael Holm; Suparna Sanyal; Scott Blanchard; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein Synthesis; Antibiotics; Fusidic acid; Viomycin; Translocation; Accuracy; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. READ MORE

  7. 5. Monitoring anti-infectives and antibiotic resistance genes : with focus on analytical method development, effects of antibiotics and national perspectives

    Author : Ghazanfar Ali Khan; Jerker Fick; Klaus Kümmerer; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; method development; on-line solid phase extraction liquid chromatography mass spectrometry SPE LC-MS MS ; antibiotics; anti-infectives; constructed wetlands CWs ; denatured gradient gel electrophoresis DGGE ; percentage removal efficiency PRE ; shannon index; antibiotic resistance genes ARGs ; real-time polymerase chain reaction RT-PCR ; drug formulation facilities DFF ; wastewater; epidemiology; pandemic; influenza; compliance;

    Abstract : Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. READ MORE