Search for dissertations about: "oncology"

Showing result 21 - 25 of 1007 swedish dissertations containing the word oncology.

2. 21. Molecular Genetic Studies on Prostate and Penile Cancer

   Author : Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

   Abstract : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. READ MORE

4. 22. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

   Author : Ulrika Andersson; Roger Henriksson; Beatrice Malmer; Erik Blomquist; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; glioma; meningioma; endothelium; MDR; Pgp; MRP1; LRP; MGMT; EGFR; ErbB2; ErbB3; ErbB4; Onkologi; Oncology; Onkologi; onkologi; Oncology;

   Abstract : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. READ MORE

5. 23. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression

   Author : Karthik Aripaka; Maréne Landström; Jonas von Hofsten; Carl-Henrik Heldin; Ruth Palmer; Lars-Gunnar Larsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRAF6; HIF-1α; HIF-2α; HIF-3α; ALK5; Wnt3a; Hypoxic signalling; TGF-β; zebrafish; β-Catenin; Pathology; patologi; Oncology; onkologi;

   Abstract : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. READ MORE

6. 24. Islet xenotransplantation : An immunological study in the pig-to-mouse model

   Author : Birgitta Benda; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; xenotransplantation; porcine; islet; in vivo; knock-out mouse; immunohistochemistry; CsA; MDL 201; 449A; Ig; FcR; IL-6; perforin; granzyme B; macrophage; eosinophilic granulocyte; T cell; TCR; IFN- g; TNF- a; IL-2; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

   Abstract : Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. READ MORE

7. 25. Molecular Characterization of Diffuse Large B-cell Lymphoma and Aspects of Transformation

   Author : Mattias Berglund; Gunilla Enblad; Svetlana Lagercrantz; Christer Sundström; Catharina Larsson; Ingemar Ernberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Diffuse large B-cell lymphoma; Hodgkin lymphoma; follicular lymphoma; transformation; comparative genomic hybridization; prognosis; Onkologi; Oncology; Onkologi;

   Abstract : Lymphomas are a heterogeneous group of neoplasias originating from B- or T-lymphocytes. In this thesis, we determined the genetic and immunophenotypic characterization of DLBCL and their prognostic impact. READ MORE