Search for dissertations about: "one-carbon metabolism"

Showing result 1 - 5 of 16 swedish dissertations containing the words one-carbon metabolism.

2. 1. Biomarkers of one-carbon metabolism in colorectal cancer risk

   Author : Björn Gylling; Richard Palmqvist; Katarina Bälter; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; one-carbon metabolism; biomarkers; folate; epidemiology; Cancer Epidemiology; cancerepidemiologi;

   Abstract : One-carbon metabolism, a network of enzymatic reactions involving the transfer of methyl groups, depends on B-vitamins as cofactors, folate as a methyl group carrier, and amino acids, betaine, and choline as methyl group donors. One-carbon metabolism influences many processes in cancer initiation and development such as DNA synthesis, genome stability, and histone and epigenetic methylation. READ MORE

4. 2. Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways

   Author : Mattias Johansson; Pär Stattin; Henrik Grönberg; Fredrik Wiklund; Jenny Chang-Claude; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology and andrology; Urologi och andrologi;

   Abstract : The aim of this thesis was to investigate the involvement of the insulin-like growth factor- and the one-carbon metabolism pathways in prostate cancer aetiology, studying both circulating biomarkers and genetic variation. Papers included in the thesis were conducted within the case-control study CAncer Prostate in Sweden (CAPS), and the two prospective studies European Prospective Investigation into nutrition and Cancer (EPIC), and Northern Sweden Health and Disease Cohort (NSHDC). READ MORE

5. 3. Diet and gastrointestinal cancer : one-carbon metabolism and other aspects

   Author : Susanna C Larsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Diet has been hypothesized to play a major role in the etiology of gastrointestinal cancer, but the specific dietary factors involved remain unclear. The aims of this thesis were: to examine the associations of dietary magnesium and vitamin B6 intakes with risk of colorectal cancer in the Swedish Mammography Cohort (SMC); to evaluate the relation between folate intake and risk of pancreatic cancer in the SMC and the Cohort of Swedish Men (COSM); to use metaanalysis to summarize the evidence from published studies of the associations of folate intake and polymorphisms in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), a central enzyme in one-carbon metabolism, with risk of esophageal, gastric, pancreatic, and colorectal cancer; and to perform a meta-analysis of epidemiologic studies of the relationship between processed meat consumption and risk of gastric cancer. READ MORE

6. 4. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

   Author : Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

   Abstract : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. READ MORE

7. 5. Metabolic Risk Factors and Molecular Subtypes of Colorectal Cancer

   Author : Robin Myte; Bethany van Guelpen; Richard Palmqvist; Jenny Häggström; Matty Weijenberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; risk factors; metabolic syndrome; one-carbon metabolism; molecular subtypes; KRAS; BRAF; MSI; molecular pathological epidemiology; Cancer Epidemiology; cancerepidemiologi;

   Abstract : Background: Colorectal cancer (CRC) is a heterogeneous disease developing from distinct pathways, resulting in tumor subtypes with large differences in clinical and molecular characteristics. Molecular characteristics are increasingly being used clinically to guide therapy. READ MORE