Search for dissertations about: "one-sample approach"

Found 5 swedish dissertations containing the words one-sample approach.

2. 1. Monitoring gene level biodiversity - aspects and considerations in the context of conservation

   Author : Johan Charlier; Linda Laikre; Nils Ryman; Kjetil Hindar; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; brown trout; conservation genetics; genetic drift; genetic monitoring; effective population size; moose; one-sample approach; spatial genetic structure; statistical power; temporal data; populationsgenetik; Population Genetics;

   Abstract : The objectives of this thesis relate to questions needed to be addressed in the context of genetic monitoring for implementing the Convention on Biological Diversity for the gene level. Genetic monitoring is quantifying temporal changes in population genetic metrics. READ MORE

4. 2. Screening, Targeting, Tailoring, and Implementation in Primary Health Care : An integrated physical therapy and behavioural medicine approach to persons with persistent musculoskeletal pain

   Author : Maria Sandborgh; Eva Denison; Per Lindberg; Christina Opava; Uppsala universitet; []
   Keywords : Caring sciences; physical therapy; behavioural medicine; screening; chronic pain; primary health care; Vårdvetenskap;

   Abstract : This thesis deals with a behavioural medicine approach to the management of patients with persistent musculoskeletal pain in primary health care physical therapy. The main aims of the thesis were; to develop, and evaluate the psychometric properties of, a screening instrument for risk of disability and; to evaluate the implementation and effects of a targeted and tailored treatment. READ MORE

5. 3. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

   Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE

6. 4. Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome

   Author : Chen Suo; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) is transcribed to messenger ribonucleic acid (mRNA), and then translated into proteins; dysfunction in any of these processes may contribute to the development of disease. READ MORE

7. 5. Non-linear model applied on composites exhibiting inelastic behavior: development and validation

   Author : Liva Pupure; Maciej Wysocki; Luleå tekniska universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Polymera konstruktionsmaterial; Polymeric Composite Materials;

   Abstract : The polymeric composite materials are in high demand by industries where light and strong materials are required. Although manmade fiber (e.g. glass, carbon, aramid fibers) are most often used to reinforce polymers, natural fibers due to their environmental friendliness and sustainability have been also considered. READ MORE