Search for dissertations about: "opioid"

Showing result 1 - 5 of 177 swedish dissertations containing the word opioid.

  2. 1. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

    Author : Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

    Abstract : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. READ MORE

  4. 2. Evolution of the Neuropeptide Y and Opioid Systems and their Genomic Regions

    Author : Görel Sundström; Dan Larhammar; Manfred Schartl; Uppsala universitet; []
    Keywords : neuropeptide Y; opioid; evolution; genome duplication; gene duplication; Hox; SCN; IGFBP; MEDICINE; MEDICIN;

    Abstract : Two whole genome duplications (2R) occurred early in vertebrate evolution. By using combined information from phylogenetic analyses and chromosomal location of genes, this thesis delineates the evolutionary history of two receptor-ligand systems that expanded by these large scale events. READ MORE

  5. 3. Quantitative Aspects of Nanodelivery Across the Blood-Brain Barrier : Exemplified with the Opioid Peptide DAMGO

    Author : Annika Lindqvist; Margareta Hammarlund-Udenaes; Markus Fridén; William Elmquist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood-brain barrier; liposomes; nanocarriers; brain delivery; pharmacokinetics; modeling and simulation; microdialysis; opioid peptide; DAMGO; LC-MS MS; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. READ MORE

  6. 4. Long-term Effects of Opioids in the Treatment of Chronic Pain : Investigation of Problems and Hazards on Clinical, Biochemical, Cellular and Genetic Levels

    Author : Annica Rhodin; Torsten Gordh; Fred Nyberg; Mats Stridsberg; Mats Enlund; Harald Breivik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; opioid; chonic pain; long-term opioid treatment; Anaesthetics; Anestesiologi; Anestesiologi; Anaesthesiology;

    Abstract : After two decades of liberal prescribing of opioids, there has been an increasing recognition of problems connected to the prolonged use of opioids for chronic pain. The aim of my thesis was to explore some consequences of long-term opioid treatment for chronic pain such as problematic opioid use, endocrine disorders, tolerance and genetic variations in pain and opioid response. READ MORE

  7. 5. Opioid and non-opioid activities of the dynorphins

    Author : Zoya Marinova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN). Dynorphins regulate pain processing and memory acquisition and modulate reward induced by intake of addictive substances. READ MORE