Search for dissertations about: "optical DNA mapping"

Showing result 1 - 5 of 10 swedish dissertations containing the words optical DNA mapping.

  2. 1. Optical Mapping of Bacterial Plasmids

    Author : Vilhelm Müller; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; competitive binding; optical mapping; fluorescence microscopy; DNA; plasmids; CRISPR Cas9; antibiotic resistance; nanofluidics; single-molecule;

    Abstract : Bacteria that have acquired resistance to antibiotics represent one of the largest threats to human health and modern health care. The genes encoding resistance are frequently spread via the transfer of plasmids, which are circular double stranded DNA molecules separate from the chromosomal DNA of the bacteria. READ MORE

  4. 2. Development of methods for optical mapping of nanoconfined DNA

    Author : Lena Nyberg; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; competitive binding; optical mapping; YOYO-1; nanofluidics; antibiotic resistance; fluorescence microscopy; single-molecule; DNA; plasmids; netropsin;

    Abstract : .... READ MORE

  5. 3. Methods for barcode analysis in optical DNA mapping

    Author : Albertas Dvirnas; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA Barcoding; Optical Mapping; Computational Biology;

    Abstract : This thesis is composed of six papers, which all concern different methods and tools used for the analysis of barcodes in nanochannel-based Optical DNA Mapping (ODM). The first four papers consider densely-labeled barcodes while the last two consider sparsely-labeled barcodes. READ MORE

  6. 4. Competitive-Binding Based Optical DNA Mapping - From Bacterial Plasmids to the Human Genome

    Author : Vilhelm Müller; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; genetics; single-molecule; nanofluidics; DNA; antibiotic resistance; optical DNA mapping; plasmids; competitive binding; fluorescence microscopy; bacteria;

    Abstract : Significant advances within the field of DNA sequencing have allowed us to study DNA at a level of detail that was previously impossible. However, dynamic genomic regions with a high degree of structural variations, while being linked to disease in humans and increased resistance to antibiotics, are still challenging to characterize. READ MORE

  7. 5. Single DNA Molecule Analysis – New Tools for Medical Diagnosis

    Author : My Nyblom; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; optical DNA mapping; DNA damage; DNA; single-molecule analysis; fluorescence microscopy; antibiotic resistance; nanofluidics; genetics;

    Abstract : The DNA molecule, the blueprint of life, contains an enormous amount of information. The information is coded by the combination of four bases; adenine, cytosine, guanine, and thymine, that, together with the sugar-phosphate backbones, make up the DNA double helix. READ MORE