Search for dissertations about: "optimal designs"

Showing result 1 - 5 of 173 swedish dissertations containing the words optimal designs.

2. 1. Optimal adaptive designs and adaptive randomization techniques for clinical trials

   Author : Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

   Abstract : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. READ MORE

4. 2. Topics in optimal design of experiments

   Author : Sofia Normark; Hans Nyquist; Johan Lyhagen; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; optimal design; factorial experiments; minimax designs; efficiency; locally optimal designs; generalized linear models; binary data; statistik; Statistics;

   Abstract : This thesis contributes to optimal design of experiments in situations where the optimal design depends on unknown parameters. Such situations often occur when the response variable does not have normal distribution, as is the case with many generalized linear models (GLM) and many models for binary response. READ MORE

5. 3. Optimal Subsampling Designs Under Measurement Constraints

   Author : Henrik Imberg; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; inverse probability weighting; unequal probability sampling; optimal design; active sampling; M-estimation;

   Abstract : We consider the problem of optimal subsample selection in an experiment setting where observing, or utilising, the full dataset for statistical analysis is practically unfeasible. This may be due to, e.g., computational, economic, or even ethical cost-constraints. READ MORE

6. 4. Estimation and optimal designs for multi-response Emax models

   Author : Bergrún Tinna Magnúsdóttir; Hans Nyquist; Ziad Taib; Nancy Flournoy; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; multi-response Emax models; Clinical Utility Index CUI ; optimal designs; system estimation; dose-response studies.; Statistics; statistik;

   Abstract : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. READ MORE

7. 5. Intelligent System Designs : Data-driven Sensor Calibration & Smart Meter Privacy

   Author : Yang You; Tobias J. Oechtering; Olga Fink; KTH; []
   Keywords : Electrical Engineering; Elektro- och systemteknik;

   Abstract : Nowadays, the intelligent system has gained high popularity in successful implementation of real-time tasks due to its capability of providing efficient and powerful decision making in real applications. In this thesis, we aim for exploring and exploiting different concepts or methods to handle different tasks towards the intelligent system design. READ MORE