Search for dissertations about: "optimal experimental design"

Showing result 1 - 5 of 164 swedish dissertations containing the words optimal experimental design.

2. 1. Optimal design for dose-finding studies

   Author : Renata Eirini Tsirpitzi; Frank Miller; Kirsten Schorning; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bivariate model; distortion; drug combination; Elfving set; Emax model; Fedorov algorithm; mixed effects models; optimal experimental design; Statistics; statistik;

   Abstract : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. READ MORE

4. 2. Experimental Designs at the Crossroads of Drug Discovery

   Author : Ing-Marie Olsson; Svante Wold; Johan Gottfries; Michael Sjöström; Bo Nordén; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; Organic chemistry; Organisk kemi;

   Abstract : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. READ MORE

5. 3. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models

   Author : Joakim Nyberg; Andrew C. Hooker; Mats O. Karlsson; Sergei Leonov; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; robust design; optimizing drug development; population models; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. READ MORE

6. 4. Test Design for Mean Ability Growth and Optimal Item Calibration for Achievement Tests

   Author : Jonas Bjermo; Frank Miller; Marie Wiberg; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; test design; item response theory; optimal experimental design; SweSAT; item calibration; vertical scaling; ability growth; computerized adaptive tests; Statistics; statistik;

   Abstract : In this thesis, we examine two topics in the area of educational measurement. The first topic studies how to best design two achievement tests with common items such that a population mean-ability growth is measured as precisely as possible. The second examines how to calibrate newly developed test items optimally. READ MORE

7. 5. Achievement tests and optimal design for pretesting of questions

   Author : Mahmood Ul Hassan; Frank Miller; Steven Gilmour; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Achievement test; Equivalence theorem; Exchange algorithm; Item calibration; Item response theory model; Optimal experimental design; Statistics; statistik;

   Abstract : Achievement tests are used to measure the students' proficiency in a particular knowledge. Computerized achievement tests (e.g. GRE and SAT) are usually based on questions available in an item bank to measure the proficiency of students. READ MORE