Search for dissertations about: "optimizing drug development"

Showing result 11 - 15 of 21 swedish dissertations containing the words optimizing drug development.

  2. 11. Quantitative Clinical Pharmacological Studies on Efavirenz and Atazanavir in the Treatment of HIV-1 Infection

    Author : Dinko Rekić; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; Pharmacokinetics; Pharmacodynamics; Pharmacometrics; AIDS;

    Abstract : There are 34 million people infected with the HIV-1 virus in the world today. Due to increased access to antiretroviral therapy, AIDS related death has dropped by 30% since 2005. READ MORE

  4. 12. Modelling of tolerance and rebound in normal and diseased rats

    Author : Christine Ahlström; Göteborgs universitet; []
    Keywords : feedback modelling; tolerance; rebound; pharmacokinetics; pharmacodynamics; dyslipidaemia; nicotinic acid; non-esterified fatty acids;

    Abstract : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. READ MORE

  5. 13. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

    Author : Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). READ MORE

  6. 14. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

    Author : Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. READ MORE

  7. 15. Relationship Between Crystal Structure and Mechanical Properties in Cocrystals and Salts of Paracetamol

    Author : Hamzah Ahmed; Ingvar Ymén; Luleå tekniska universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Health Science; Hälsovetenskap;

    Abstract : Oral tablets are convenient and widely administered drugdosage forms.The mechanical properties of a drug substance such as plasticity, ability to cohere into compacts and friction/adhesion are important in the development of a tablet formulation. READ MORE