Search for dissertations about: "optimizing drug development"

Showing result 16 - 20 of 21 swedish dissertations containing the words optimizing drug development.

  2. 16. Preclinical studies of roscovitine

    Author : Marina Vita; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

    Abstract : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. READ MORE

  4. 17. Improving the immunogenicity of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nearly 30 years have passed since the start of the global HIV epidemic and we are still unable to control the spread of the virus. HIV predominately infects cells crucial for the function of the immune system, integrates into the host genome and demonstrates a huge genetic variability, and the use of therapeutic antiretroviral drugs can restrain but not clear the infection. READ MORE

  5. 18. Optimization of the formulation and design of oligonucleotide-based pharmaceuticals for the purpose of gene therapy

    Author : Eman M Zaghloul; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oligonucleotides (ONs) are short sequences of nucleic acids which may be used in a therapeutic context to modulate gene expression. According to their target, ONs can be classified into two main classes: antisense ONs which target mRNA and antigene ONs that target chromosomal DNA. READ MORE

  6. 19. Functional genomics at the interface of protein expression and biophysical analysis

    Author : Xiaoqiu Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein characterization is central to any functional genomics effort, hence protein expression and purification play fundamental roles in these initiatives. In this study strategies for protein expression in E. coli were analysed, and several parameters were investigated respect to high-level expression of functional proteins. READ MORE

  7. 20. Trophic factors, neuroprotection and spinal cord repair

    Author : Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Abstract : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. READ MORE