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Showing result 1 - 5 of 58 swedish dissertations matching the above criteria.

  1. 1. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery

    Author : Eva Krondahl; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; opioid peptides; permeability; metabolism; oral delivery; pulmonary delivery; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. READ MORE

  2. 2. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

    Author : Cecilia Wadell; Frans Merkus; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. READ MORE

  3. 3. Swedish School-leaving Students' Oral Proficiency in English : Grading of Production and Analysis of Performance

    Author : Stellan Sundh; Merja Kytö; Torsten Lindblad; Sauli Takala; Uppsala universitet; []
    Keywords : HUMANITIES; HUMANIORA; HUMANIORA; HUMANITIES; Linguistics; second language learning; oral testing; rating criteria; oral proficiency; grading spoken English; student production; validity; reliability; 19-year-old Swedish learners; Lingvistik; Linguistics; Lingvistik; English; Engelska;

    Abstract : This study deals with the testing and grading of Swedish school leaving students’ oral proficiency in English, and with certain aspects of these students’ linguistic competence. The analyses and results are based on material drawn from an assessment project carried out at Gothenburg University in 1993. READ MORE

  4. 4. Public Reading and Aural Intensity : An Analysis of the Soundscape in John 1–4

    Author : Dan Nässelqvist; Bibelvetenskap; []
    Keywords : HUMANIORA; HUMANITIES; Gospel of John; Public Reading; Lector; Oral Delivery; Oral Performance; Sound Analysis; Sound Mapping; Sound Structure; Soundscape; Aural Intensity; Comma; Colon; Period; Colometry; Performance Criticism; Rhetorical Figure; Manuscripts; P46; P66; P75; Lectional Signs; Reader’s Aids; Private Reading;

    Abstract : This study investigates the public reading of New Testament writings in early Christian communities during the first two centuries C.E. from the perspective of the lectors who prepared and performed the readings. READ MORE

  5. 5. Vesicle-mediated and free soluble delivery of bacterial effector proteins by oral and systemic pathogens

    Author : Bernard Thay; Jan Oscarsson; Mikael Rhen; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Periodontitis; Aggregatibacter actinomycetemcomitans; Staphylococcus aureus; membrane vesicles; vesicle-host cell interaction; protein delivery; molekylärbiologi; Molecular Biology;

    Abstract : Periodontitis, the primary cause of tooth-loss worldwide, is a bacterially induced chronic inflammatory disease of the periodontium. It is associated with systemic conditions such as cardiovascular disease (CVD). However, pathogenic mechanisms of periodontitis-associated bacteria that may contribute to the CVD association are unclear. READ MORE