Search for dissertations about: "orexin-B"

Found 3 swedish dissertations containing the word orexin-B.

  2. 1. Effects of Orexins, Guanylins and Feeding on Duodenal Bicarbonate Secretion and Enterocyte Intracellular Signaling

    Author : Magnus Wilhelm Bengtsson; Gunnar Flemström; Olof Nylander; Karl E. O. Åkerman; Per M. Hellström; Uppsala universitet; []
    Keywords : Physiology; alkaline secretion; carbohydrates; central nervous system; cholinergic stimulation; duodenum; enteric nervous system; enterochromaffin cell; fasting; feeding; glucose; guanylyl cyclase C; humans; hypocretin; intra-arterial; in situ; intracerebroventricular; luminal acid; luzindole; orexin-B; SB-334867; Fysiologi;

    Abstract : The duodenal epithelium secretes bicarbonate ions and this is regarded as the primary defence mechanism against the acid discharged from the stomach. For an efficient protection, the duodenum must also function as a sensory organ identifying luminal factors. READ MORE

  4. 2. Orexin Receptors in Recombinant CHO Cells : Signaling to Short- and Long-Term Cell Responses

    Author : Sylwia Ammoun; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Christer Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; orexins; cell signaling; Neurovetenskap; Neurology; Neurologi;

    Abstract : Recently discovered neuropeptides orexins (orexin-A and -B) act as endogenous ligands for G-protein-coupled receptors called OX1 and OX2 receptors. Our previous studies have established model systems for investigation of the pharmacology and signaling of these receptors in recombinant CHO cells. READ MORE

  5. 3. OX1 Orexin Receptor Signalling to Phospholipases

    Author : Marie Ekholm; Jyrki Kukkonen; Graeme Milligan; Uppsala universitet; []
    Keywords : orexin; phospholipase; Calcium; cell signalling; G protein coupled receptor; ERK; live-cell imaging; arachidonic acid; diacylglycerol;

    Abstract : The neuropeptides orexin-A and orexin-B were discovered in 1998 and were first described as regulators of feeding behaviour. Later research has shown that they have an important role in the regulation of sleep. Two G protein-coupled receptors, OX1 and OX2 orexin receptors, mediate the cellular responses to orexins. READ MORE