Search for dissertations about: "organic"

Showing result 6 - 10 of 3300 swedish dissertations containing the word organic.

2. 6. Design and Synthesis of Serine and Aspartic Protease Inhibitors

   Author : Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; Organic synthesis; Organisk syntes;

   Abstract : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. READ MORE

4. 7. Engineering Candida antarctica Lipase A for Enantioselective Transformations in Organic Synthesis : Design, Immobilization and Organic Solvent Screening of Smart Enzyme Libraries

   Author : Ylva Wikmark; Jan-Erling Bäckvall; Romas Kazlauskas; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica Lipase A; protein engineering; enzyme libraries; enzyme immobilization; biocatalysis; organisk kemi; Organic Chemistry;

   Abstract : The use of enzymes as catalysts in organic synthesis constitutes an attractive alternative to conventional chemical catalysis. Enzymes are non-toxic and biodegradable and they can operate under mild reaction conditions. READ MORE

5. 8. Organic Heavy Group 14 Element Compounds : A Study of Their Chemical Bonding Properties Directed Towards Applications as Molecular Wires and in Synthesis

   Author : Julius Tibbelin; Henrik Ottosson; Christoph Marschner; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Silicon; Group 14 Elements; Silenes; Conjugation; Chemical Bonding; Electronic Structure; Protecting Group Chemistry; Physical organic chemistry; Fysikalisk organisk kemi; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

   Abstract : The research described herein includes synthesis, spectroscopy, and quantum chemical calculations with focus on the characteristic properties of compounds with bonds between carbon and the heavier Group 14 elements.The chapters based on the first four papers concern σ- and σ/π-conjugated compounds, although the focus of the first paper is on ring strain of bicyclo[1. READ MORE

6. 9. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

   Author : Ola Åberg; Bengt Långström; Nicholas Long; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; [11C]carbon monoxide; isotopic labelling; PET; acrylamide; EGFR; VEGFR-2; 11C; Organic chemistry; Organisk kemi; Organic Chemistry; Organisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

   Abstract : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. READ MORE

7. 10. New Methodologies in Organic Chemistry: Applications to the Synthesis of α-Amino Acids and Natural Products

   Author : Sebastian Hirner; Peter Somfai; Varinder Aggarwal; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; 2-Vinylaziridines; 3-Pyrrolines; Ringexpansion; Rearrangement; Anisomycin; Total synthesis; α-Amino acids; Arylglycines; Weinreb amides; α-Arylation; Grignard reagents; Umpolung; Organic chemistry; Organisk kemi;

   Abstract : This thesis deals with the development and application of new synthetic methodology in organic chemistry. The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. READ MORE