Search for dissertations about: "organotypic culture"

Showing result 11 - 15 of 18 swedish dissertations containing the words organotypic culture.

  2. 11. Interaction between nerve fiber formation and astrocytes

    Author : Sanazalsadat Hashemian; Ingrid Strömberg; Elisabet Åkesson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; spinal cord; CSPG; CD47;

    Abstract : Parkinson’s disease, the second most common neurodegenerative disorder,is characterized by loss of nigrostriatal dopaminergic neurons. To date,there is no defined cause and cure for the disease. An ideal treatmentstrategy is to replace the lost neurons by transplanting fetal dopaminergicneurons to the brain of parkinsonian patients. READ MORE

  4. 12. Stem cell interactions with the injured brain

    Author : Linda Maria Jäderstad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurodegenerative diseases such as Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis and acute neurological disorders such as brain ischemia and traumatic injury yearly affect millions of people. Neural stem cell (NSC) grafting is an emerging strategy to treat and potentially cure these conditions for which today no effective remedies exist. READ MORE

  5. 13. In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5

    Author : Anne Jämsä; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main hallmarks of Alzheimer’s disease (AD) are extracellular deposits of betaamyloid (Aβ) and intracellular neurofibrillary tangles (NFT) composed of highly phosphorylated tau protein. Abnormal hyperphosphorylation of tau is the most deleterious step in NFT formation making the use of kinase inhibitors an attractive treatment possibility in AD. READ MORE

  6. 14. Innate immune airway responses after exposure to ultrafine and ambient particles : in vivo and in vitro models

    Author : Anna Steneholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inhalation of ultrafine and ambient particles in the air triggers a response in the innate immune system of the airways. This thesis explores measures to reduce exposure to organic dust, to dampen the adverse immune effects of chronic organic swine dust exposure and develop a refined in vitro bronchial mucosa model to reduce in vivo toxicity testing on humans and animals. READ MORE

  7. 15. Oxidative stress in cell and tissue damage and selenium-based therapeutics in cancer

    Author : Rim Jawad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Redox homeostasis is the balance between cellular prooxidants and antioxidants, maintained by the interplay of electrons. Reactive oxygen species (ROS) is a term for molecules with unpaired valence electrons or unstable bonds. READ MORE