Search for dissertations about: "organotypic culture"

Showing result 6 - 10 of 18 swedish dissertations containing the words organotypic culture.

  2. 6. Modeling of multi-step oral carcinogenesis in vitro : assessment of growth, differentiation and apoptosis markers

    Author : Annette Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Organotypic cultures; apoptosis; terminal squamous differentiation; buccal mucosa; cytokeratins; carcinogenesis; p53;

    Abstract : Human oral mucosa, especially the buccal epithelium, is worldwide a common site for cancer. Cancer development frequently results in inactivation of tumor suppressor p53, a central regulator of growth and programmed cell death, and deregulated expression of structural elements like cytokeratins. READ MORE

  4. 7. Investigations into the distribution and function of nucleobindin 1

    Author : Paul Williams; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nucleobindin proteins (NUCB1 and NUCB2) are both characterised by DNA- and calcium-binding motifs. The functionality of these motifs has been demonstrated, but has not yet led to the identification of a role for either protein. READ MORE

  5. 8. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

    Author : Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. READ MORE

  6. 9. The breathing brainstem : development of inspiration

    Author : David Forsberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breathing is essential for life, and yet we do not fully understand the mechanisms that control it. The main central pattern generators for respiration include the inspiratory generating region called the preBötzinger Complex (preBötC), and the chemosensitive region called the parafacial respiratory group/retrotrapezoid nucleus (pFRG/RTN). READ MORE

  7. 10. Ischemic Cell Death in the CNS - applications of a new in vitro model

    Author : Tobias Cronberg; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; Neurology; astrocyte; stroke; adenosine; hyperglycaemia; glucose; free radicals; calcium; in vitro; brain ischemia; slice; neuropsychology; neurofysiologi; neurophysiology;

    Abstract : Ischemic brain damage is a common cause of death and disability. A global ischemic insult is usually the result of a transient cardiac arrest while occlusion of cerebral blood vessels leads to focal ischemic lesions, commonly termed stroke. READ MORE