Search for dissertations about: "orphan receptors"

Showing result 1 - 5 of 29 swedish dissertations containing the words orphan receptors.

  2. 1. Discovery of Novel Receptors for Lipid Mediators - a study leading to the identification of receptors involved in metabolism and the immune system

    Author : Niclas Nilsson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; Thiazolidinedione; SCFA; FFA; FFA2R; FFA1R; GPR43; GPR41; GPR40; BLT2; GPCR; Orphan; Receptor;

    Abstract : Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. READ MORE

  4. 2. G Protein-Coupled Receptors; Discovery of New Human Members and Analyses of the Entire Repertoires in Human, Mouse and Rat

    Author : David E. Gloriam; Helgi Schiöth; Robert Fredriksson; Darren Flower; Uppsala universitet; []
    Keywords : Bioinformatics; G protein-coupled receptor; GPCR; Bioinformatics; Evolution; Orphan; Rhodopsin; Adhesion; Phylogeny; Bioinformatik;

    Abstract : G protein-coupled receptors (GPCRs) are signal mediators that have a prominent role in the regulation of physiological processes and they make up the targets for 30-45% of all drugs. Papers I and II describe the discovery of new human GPCRs belonging to the Rhodopsin family, a family which contains many common drug targets. READ MORE

  5. 3. Functional studies on the orphan receptor Nurr1 and related retinoid receptors

    Author : Diogo Sampaio e Castro; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) constitute a large family of ligand-inducible transcription factors which includes receptors for steroid hormones, retinoids (vitamin A derivatives), vitamin D an d thyroid hormone. The family also includes a large number of structurally related proteins that lack identified ligands and are therefore refered to as orphan receptors. READ MORE

  6. 4. Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs)

    Author : Katarina Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogens influence post-natal development and function of the female reproductive system and other organs including bone and cardiovascular system. Estrogens are also involved in the development and growth of certain cancers in e.g. breast and uterine endometrium. READ MORE

  7. 5. NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection

    Author : Nikolaos Volakakis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : NR4A receptors show distinct properties that make them unique within the family of nuclear receptors. They lack a ligand-binding cavity and a canonical coactivator-binding site and they are induced both in vivo and in vitro in an immediate early way by an extremely wide repertoire of substances/conditions. READ MORE