Search for dissertations about: "orthologs"

Showing result 1 - 5 of 43 swedish dissertations containing the word orthologs.

  2. 1. The labyrinth of protein classification: a pipeline forselection and classification of biological data

    Author : Benedetta Pelosi; Neus Visa; Antonio Barragan; Stefan Jansson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pipeline; filtering; machine learning; deep learning; computational biology; bioinformatics; mitochondrial metabolism; carotenoid biosynthesis; orthologs; protein analyses; statistics; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics; statistik; Statistics;

    Abstract : Recent progress in fundamental biological sciences and medicine has considerably increased the quantity ofdata that can be studied and processed. The main limitation now is not retrieving data, but rather extractinguseful biological insights from the large datasets accumulated. READ MORE

  4. 2. Functional Inference from Orthology and Domain Architecture

    Author : Mateusz Kaduk; Erik Sonnhammer; Erich Bornberg-Bauer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Orthology; Functional coupling networks; Association networks; Hierarchical groups of orthologs; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Proteins are the basic building blocks of all living organisms. They play a central role in determining the structure of living beings and are required for essential chemical reactions. One of the main challenges in bioinformatics is to characterize the function of all proteins. READ MORE

  5. 3. Deciphering molecular mechanisms in the evolution of new functions

    Author : Hind Abdalaal; Joakim Näsvall; Paul Rainey; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolvability; functional trade-offs; collateral toxicity; duplication and amplification; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : The evolution of new genes and functions is considered to be a major contributor to biological diversity in organisms. Through de novo origination, “duplication and divergence”, and horizontal gene transfer, organisms can acquire new genetic material that can evolve to perform novel functions. READ MORE

  6. 4. Analyses of protein evolution, function, and architecture

    Author : Anna Henricson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proteins can evolve over time in many different ways. An ancestral protein sequence inherited in different species will gradually undergo changes in primary sequence and sometimes in domain architecture. Some of these changes will affect its function, and evolutionary analyses can be used to predict function shift. READ MORE

  7. 5. Big data networks and orthology analysis

    Author : Emma Persson; Erik Sonnhammer; Albert László Barabási; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ortholog; protein domain; functional association network; pathway enrichment analysis; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Understanding biological systems in complex organisms is important in life science in order to comprehend the interplay of genes, proteins, and compounds causing complex diseases. As biological systems are intricate, bioinformatics tools, models, and algorithms are of the utmost importance to understand the bigger picture and decipher biological meaning from the vast amounts of information available from biological experiments and predictions. READ MORE