Search for dissertations about: "orthology"

Showing result 1 - 5 of 17 swedish dissertations containing the word orthology.

2. 1. The relationship between orthology, protein domain architecture and protein function

   Author : Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Abstract : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. READ MORE

4. 2. Functional Inference from Orthology and Domain Architecture

   Author : Mateusz Kaduk; Erik Sonnhammer; Erich Bornberg-Bauer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Orthology; Functional coupling networks; Association networks; Hierarchical groups of orthologs; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : Proteins are the basic building blocks of all living organisms. They play a central role in determining the structure of living beings and are required for essential chemical reactions. One of the main challenges in bioinformatics is to characterize the function of all proteins. READ MORE

5. 3. Inference of functional association networks and gene orthology

   Author : Thomas Schmitt; Erik L. L. Sonnhammer; Søren Brunak; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; orthology; InParanoid; FunCoup; systems biology; biological networks; network inference; functional coupling; functional association; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Abstract : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. READ MORE

6. 4. Novel resources enabling comparative regulomics in forest tree species

   Author : David Sundell; Torgeir Hvidsten; Klaas Vandepoele; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Comparative genomics; Web resource; Wood development; RNA-Seq; Forestry; Lignocellulose; Regulomics; High-spatial resolution; Populus tremula; Picea abies; Orthology.; biology; biologi; molekylär bioteknik inst f nat vet biokemi ; molecular biotechnology dept of biochem ;

   Abstract : Lignocellulosic plants are the most abundant source of terrestrial biomass and are one of the potential sources of renewable energy that can replace the use of fossil fuels. For a country such as Sweden, where the forest industry accounts for 10% of the total export, there would be large economical benefits associated with increased biomass yield. READ MORE

7. 5. Orthology and protein domain architecture evolution

   Author : Volker Hollich; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : A major factor behind protein evolution is the ability of proteins to evolve new domain architectures that encode new functions. Protein domains are widely considered to constitute the "atoms" of protein chains, acting as building blocks of proteins as well as evolutionary units. READ MORE