Search for dissertations about: "osteonecrosis"
Showing result 1 - 5 of 12 swedish dissertations containing the word osteonecrosis.
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1. Osteonecrosis. Prognosis and Prevention of the Consequences of Osteonecrosis
Abstract : Abstract Background Osteonecrosis (ON) is defined by the in situ death of bone cells, osteocytes, hematopoietic and fatty marrow precursor cells. Events and risk factors known to be associated with ON are femoral neck fracture, hip dislocation, slipped capital femoral epiphysis in children, humeral head fracture and insufficiency fractures in load-bearing joints. READ MORE
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2. Bisphosphonates for orthopedic applications. Studies in rat models
Abstract : Prosthetic loosening, bone graft resorption and osteonecrosis are examples of problems in orthopedic surgery caused by or augmented by bone resorption. Bone resorption is caused by osteoclasts. Osteoclasts can be inactivated with biphosphonates, a drug in clinical use against osteoporosis and osteolytic tumors. READ MORE
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3. Benefits and harms of Bisphosphonates : an observational study
Abstract : Background: Bisphosphonates are first-line treatment for osteoporosis, but osteoporosis is considered an undertreated disease. The general aim of this dissertation was to further study the benefits and harms of bisphosphonates. READ MORE
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4. Medication-related osteonecrosis of the jaw : occurence, risk factors, pathogenesis & treatment
Abstract : The antiresorptive drugs bisphosphonates and denosumab arewidely used to preserve bone strength by inhibiting osteoclast mediatedbone resorption. High dose intravenous bisphosphonatesand high dose denosumab are mainly used to treat skeletal relatedevents in patients with metastatic bone disease such as metastaticbreast cancer and metastatic prostate cancer or in patients withmultiple myeloma. READ MORE
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5. Effects of antiresorptive agents on inflammation and bone regeneration in different osseous sites - experimental and clinical studies
Abstract : The biological mechanisms involved in bone regeneration in osteoporotic bone and the effect of antiresorptive drugs in relation to surgically inserted biomaterials are not fully understood. Improved osseointegration of titanium implants but also adverse effects of antiresorptive therapies, such as osteonecrotic jaw have been described in the literature. READ MORE