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Showing result 1 - 5 of 20 swedish dissertations matching the above criteria.

  2. 1. The role of Lhx2 in hair follicle morphogenesis and regeneration

    Author : Gunilla Törnqvist; Leif Carlsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : Hair is important for thermoregulation, physical protection, sensory activity, seasonal camouflage and social interactions. Hair is produced in hair follicles (HFs), complex mini-organs in the skin devoted to this task. READ MORE

  4. 2. Hair cell and organ of corti responses to normal and intense acoustic stimulation

    Author : Anders Fridberger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cochlea; outer hair cells; calcium; pressure changes; micromechanics; noise-induced hearing loss; fluorescent indicators; laser interferometry; temporal bone preparation; guinea pig;

    Abstract : The principal aims of the studies described in this thesis were to develop an in vitro model for studying acoustic overstimulation at the cellular level, to define the electrical and mechanical response characteristics of the perfused temporal bone preparation, and to investigate the effects of intense sound stimulation on the calcium levels of the hair cells in the intact hearing organ. In the in vitro model for acoustic overstimulation, isolated cochlear outer hair cells were subjected to a pressure jet emanating from a glass micropipette aimed at the cell body. READ MORE

  5. 3. Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance

    Author : Ylva Rosengardten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disease that presents some features of accelerated aging. Children with the disease are born appearing healthy but start to develop signs of the disease within their first years of life. READ MORE

  6. 4. The diagnosis and protection of the auditory peripheral system

    Author : Mao Li Duan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cochlea; inner hair cell; outer hair cell; glutamate; post-synaptic receptor; auditory brainstem response; forward masking; noise trauma; hearing loss;

    Abstract : The main focus of this thesis is on the diagnosis and prevention of peripheral hearing loss. An auditory evoked response measure (forward masking) was developed that specifically tests the function of the inner hair cells, independently of the outer hair cells. READ MORE

  7. 5. Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea

    Author : Katherine B Szarama; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cells in the mammalian hearing organ, the cochlea, develop a specialized patterning and cellular architecture necessary for hearing function. Cytoskeletal components, such as actin and microtubules, maintain the material and mechanical properties of these cells. READ MORE