Search for dissertations about: "oxidative damage to DNA"

Showing result 6 - 10 of 78 swedish dissertations containing the words oxidative damage to DNA.

2. 6. Mineral fibers, cigarette smoke, and oxidative DNA damage : An experimental study

   Author : Per Leandersson; Östergötlands Läns Landsting; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : This study concerns the ability of mineral fibers and cigarette smoke to generate reactive oxygen metabolites and to cause damage to DNA. The generation of hydroxyl radicals (OH") was demonstrated by using the DNA base, deoxyguanosine (dG) as a trapping agent for OH" and determining its hydroxylation to 8-hydroxydeoxyguanosine (80HdG), and oxidative DNA damage was assessed as formation of 80HdG in isolated DNA or in DNA of human lung cells in culture. READ MORE

4. 7. Role of oxidative stress response in radiosensitivity

   Author : Ali Pour Khavari; Siamak Haghdoost; Bo Stenerlöw; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Oxidative stress; radiosensitivity; 8-oxo-dG; DNA-repair; NRF2; glioblastoma; radiotherapy; molekylär biovetenskap; Molecular Bioscience;

   Abstract : The quality of the ionizing radiation (IR) can be described in terms of its nature, photons or particles, and their corresponding energies. The energy is classified in terms of High or Low linear energy transfer that will produce a different distribution of DNA damage and other molecules in the cell either by direct action or indirect action. READ MORE

5. 8. Cellular responses to combined irradiation with alpha particles and X-rays

   Author : Alice Sollazzo; Andrzej Wojcik; Alexandros Georgakilas; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiation; DNA damage; mutations; alpha particles; X-rays; mixed beam; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Mixed radiation fields, where different ionizing particles act together, are very important in radiobiology and in radiation protection. Mixed beams are not only the most common form of radiation exposure, but the prediction of their biological effect is also full of uncertainties. READ MORE

6. 9. Short and long-term effects of exposure to low dose and low dose rate of gamma radiation : using in vitro and in vivo models

   Author : Traimate Sangsuwan; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Low dose; Low dose rate; High dose rate; Ionizing radiation; Adaptive response; Senescence; Premature senescence; Oxidative stress; Drosophila embryo; Mutation; DNA repair; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Assessment of human health risks from exposure to ionizing radiation (IR) is mainly based on the extrapolation of results from epidemiological studies on populations exposed to relatively high doses and often at high dose rates (HDR). Risk estimates after exposure to low doses and in particular at low dose rates (LDR) remain controversial due to a lack of epidemiological evidence. READ MORE

7. 10. Polycyclic aromatic hydrocarbons : DNA damage and cell signaling

   Author : Åse Mattsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Oxidative stress is a threat to our wellbeing. The formation of reactive oxygen species may result in oxidative lesions in DNA and RNA. When challenging A549 cells with 18O-labeled hydrogen peroxide, we found that RNA was between 14-25 times more sensitive to [18O]-8-oxoGuo formation than [18O]-8-oxodGuo formation in DNA. READ MORE