Search for dissertations about: "oxidatively damaged proteins"

Found 3 swedish dissertations containing the words oxidatively damaged proteins.

  2. 1. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

    Author : Gabriella Brolén; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

    Abstract : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. READ MORE

  4. 2. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome

    Author : Malin Hernebring; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Embryonic Stem Cells; Proteasome; Protein Carbonylation; Advanced Glycation End products; Cell Differentiation; Oxidative stress; Aging; RNAi;

    Abstract : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. READ MORE

  5. 3. On protein oxidation, lifespan and aging in Saccharomyces cerevisiae

    Author : Hugo Aguilaniu; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; asymmetric cell division; protein oxidation; yeast; aging; signalling pathways;

    Abstract : In this thesis, we have investigated the physiology of protein oxidation and its possible role in the aging of the yeast Saccharomyces cerevisiae. There are two ways to measure yeast aging. First, they can only divide a finite number of times even when all nutrients necessary for division are provided. This is replicative aging. READ MORE