Search for dissertations about: "oxidised nucleotides"

Found 3 swedish dissertations containing the words oxidised nucleotides.

  2. 1. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

    Author : Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

    Abstract : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. READ MORE

  4. 2. Structural and functional studies of a novel Botulinum neurotoxin and of MTH1

    Author : Linda Henriksson; Pål Stenmark; Maria Selmer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Botulinum neurotoxin; botulism; cancer; gene cluster; molecular structures; MTH1; NTNH; oxidised nucleotides; progenitor complex; protein expression; protein purification; X-ray crystallography; Biochemistry; biokemi;

    Abstract : X-ray crystallography visualizes the three dimensional molecular structures of proteins at atomic resolution. Seeing the molecular structure of a biomedically interesting protein enables a higher understanding of its function. READ MORE

  5. 3. Endogenous antioxidants in human skeletal muscle and adaption in energy metabolism : with reference to exercise-training, exercise-related factors and nutrition

    Author : Michael B Svensson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : GSH; urate; Q10; Ubiquinone-10; myoblasts; muscle stem cells; high-intensity exercise; performance; overload training; adenine nucleotides; AMP deaminase; glycogen; carbohydrates.;

    Abstract : The antioxidant homeostasis is determined by a wide array of interacting cellular antioxidants, as well as being influenced by the homeostasis in energy metabolism. Changes in antioxidant homeostasis, as a consequences of altered production of reactive oxygen species (ROS). and/or by changes in the resident levels of antioxidants. READ MORE