Search for dissertations about: "oxidized lipids"

Showing result 16 - 20 of 30 swedish dissertations containing the words oxidized lipids.

  2. 16. Effects of lipid oxidation on transcriptional regulation and cell death

    Author : Mikko Ares; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; low density lipoprotein; lipid oxidation; nuclear factor-KB; activator protein-1; Iysophosphatidylcholine; tumor necrosis factor-alpha; oxysterol; Ca2 ; apoptosis; lipid accumulation;

    Abstract : Elevated levels of low density lipoprotein (LDL) in plasma are associated with an increased risk for atherosclerosis. Excessive accumulation of lipoproteins and lipids in the vascular wall is thought to lead to the development of advanced atherosclerotic lesions prone to rupture. READ MORE

  4. 17. Cell death in atherosclerosis

    Author : Milita Crisby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; carotid artery stenosis; ischemic stroke; apoptosis; necrosis; lipid peroxidation; plaque stability; pravastatin; inflammation; 27-[alpha]-hydroxylase;

    Abstract : Rupture of atherosclerotic lesions is recognized as the major cause of acute cerebrovascular and coronary syndromes. The characteristics of the typical vulnerable plaque include increased inflammatory cells at the shoulder region, a large lipid core, a thin fibrous cap with few collagen fibers and smooth muscle cells. READ MORE

  5. 18. PTPs : redox controlled regulators of cell signaling and transformation

    Author : Åsa Sandin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein tyrosine phosphatases (PTPs) are important redox regulated enzymes that control the tyrosine phosphorylation status in the cell. These studies aimed to increase the understanding on how PTPs are controlled by reversible oxidation in different pathological settings such as hypoxia and restenosis and to which extent oxidized PTPs contribute to certain diseases. READ MORE

  6. 19. Acyl-CoA thioesterases : auxiliary enzymes in peroxisomal lipid metabolism

    Author : Maria A K Westin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Peroxisomes are small organelles essential for life, which carry out a variety of functions mostly related to lipid metabolism, including α- and β-oxidation as well as the first steps of plasmalogen biosynthesis. Peroxisomal β-oxidation metabolizes many different lipids including very long-chain fatty acids, dicarboxylic fatty acids, branched-chain fatty acids, eicosanoids and certain xenobiotic fatty acids. READ MORE

  7. 20. IL-25 and B cells in atherosclerosis

    Author : Polyxeni Mantani; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-25; B cells; ILC2s; IL-5; anti-PC IgM; atherosclerosis; stroke; cardiovascular events;

    Abstract : Atherosclerosis is a chronic inflammatory disease of medium and large vessels of the body which is mainly characterized by the formation of lipid rich plaques within the arterial tissue. It is the most common cause of cardiovascular disease leading to clinical manifestations of coronary artery and cerebrovascular disease. READ MORE