Search for dissertations about: "oxysterol"

Showing result 1 - 5 of 28 swedish dissertations containing the word oxysterol.

  2. 1. Regulation of human macrophage gene expression by oxidized low density lipoprotein. Studies on tumor necrosis factor-a and global gene expression profiles

    Author : Mikael C. O. Englund; Göteborgs universitet; []
    Keywords : atherosclerosis; macrophage; gene expression; TNF-a; oxidized LDL; oxysterol; transcription factor; microarray;

    Abstract : Atherosclerosis is a multifactorial and progressive disease that is characterized by a focal thickening of the arteries caused by accumulation of lipoproteins, extracellular matrix, and the migration and proliferation of various cell types. Among the cells found in atherosclerotic lesions are macrophages, which accumulate lipids and are transformed into foam cells. READ MORE

  4. 2. Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways

    Author : Tomas Jakobsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat metabolism. Recently, the LXRs have emerged as important regulators of the innate and adaptive immune system and inflammation. READ MORE

  5. 3. Studies on the oxysterol receptor LXRβ : linking cholesterol metabolism to water transport and cell proliferation

    Author : Chiara Gabbi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Liver X Receptor β (LXRβ) is a nuclear receptor, belonging to the superfamily of ligand-­activated transcription factors. With its α isoform (LXRα), LXRβ shares more than 78% homology in its amino acid sequence, a common profile of oxysterol ligands and the heterodimerization partner, Retinoid X Receptor. READ MORE

  6. 4. On the possible use of oxysterols for the diagnosis and evaluation of patients with neurological and neurodegenerative diseases

    Author : Valerio Leoni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; Alzheimer s disease; oxysterol; central nervous system; gas chromatography-mass spectrometry; blood brain barrier; cholesterol;

    Abstract : Oxysterols are monooxygenated derivatives of cholesterol with a unique ability to pass lipophilic membranes and are involved in a number of elimination pathways for cholesterol. One of the major oxysterols in the circulation, 24S-hydroxycholesterol, is formed exclusively in the brain, mainly in neuronal cells. READ MORE

  7. 5. Effects of lipid oxidation on transcriptional regulation and cell death

    Author : Mikko Ares; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; low density lipoprotein; lipid oxidation; nuclear factor-KB; activator protein-1; Iysophosphatidylcholine; tumor necrosis factor-alpha; oxysterol; Ca2 ; apoptosis; lipid accumulation;

    Abstract : Elevated levels of low density lipoprotein (LDL) in plasma are associated with an increased risk for atherosclerosis. Excessive accumulation of lipoproteins and lipids in the vascular wall is thought to lead to the development of advanced atherosclerotic lesions prone to rupture. READ MORE