Search for dissertations about: "p 53 expression"

Showing result 1 - 5 of 13 swedish dissertations containing the words p 53 expression.

  2. 1. Cloning and characterization of a p-53-inducible gene, WIG-1

    Author : Shohreh Varmeh-Ziaie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Elucidating the mechanisms by which p53 inhibits tumor growth is a central issue in cancer research, as the TP53 gene is mutated in over half of all human cancers. Lack of functional p53 also contributes to the resistance of many tumor types to chemotherapy and radiotherapy. READ MORE

  4. 2. The p53-induced gene wig-1 : regulation of expression and role in embryonic development

    Author : Margareta Wilhelm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. More than 50% of human tumors carry mutations in the p53 gene, most of which reside within the DNAbinding core domain of p53. READ MORE

  5. 3. Cholesterol turnover in acute myelogenous leukemia with special emphasis on regulation of low density lipoprotein receptor expression in leukemic cells

    Author : Loukas Tatidis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cellular cholesterol requirements are met by receptor mediated uptake of cholesterol in low density lipoprotein (LDL) particles and/or by endogenous synthesis, the rate limiting enzyme in the synthesis pathway being 3-hydroxy-3-methylglutary coenzyme A (HMG-CoA) reductase. Expressions of both the LDL receptor and HMG-CoA reductase genes are normally under end product repression by cellular cholesterol. READ MORE

  6. 4. Long QT syndrome in Sweden : founder effects and associated cardiac phenotypes

    Author : Annika Winbo; Annika Rydberg; Eric Schulze-Bahr; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long QT Syndrome; Jervell and Lange-Nielsen Syndrome; inherited arrhythmia; founder effects; clinical genetics; haplotype analysis; mutation age; founder mutation; clinical phenotype; life-threatening cardiac events; mutation-specific; KCNQ1 gene; modifier genes; sequence variants; risk stratification; risk factor; gender; pediatrik; Pediatrics;

    Abstract : Background: We aimed to increase the knowledge regarding the familial arrhythmogenic disorder Long QT Syndrome (LQTS) and its recessive variant Jervell and Lange-Nielsen Syndrome (JLNS) in Sweden, including prevalences and clinical phenotypes. A specific focus was directed towards two KCNQ1 mutations –p.Y111C and p. READ MORE

  7. 5. Basis for reclassification of nasopharyngeal carcinoma

    Author : Jian-Yong Shao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nasopharyngeal carcinoma (NPC) shows broad differences in racial and geographical distribution, radiosensitivity, and a multifactorial etiology. This thesis aims to identify molecular biomarkers with potentially valuable for prognostic implications in NPC. READ MORE