Search for dissertations about: "p15"

Showing result 1 - 5 of 11 swedish dissertations containing the word p15.

  2. 1. Molecular Genetic Studies of Sporadic and MEN1-Associated Endocrine Pancreatic Tumors

    Author : Daniel Lindberg; Gunnar Westin; Göran Åkerström; Bo Wängberg; Uppsala universitet; []
    Keywords : Surgery; pancreatic endocrine tumor; MEN1; LOH; WNT7A; HDAC11; CDK4; CDKN2B p15; CDKN1B p27; CDKN2C p18; c-Myc; Smad4; pyrosequencing; epigenetic; methylation; tumor suppressor; Kirurgi;

    Abstract : Pancreatic endocrine tumors (PETs) may cause typical syndromes of hormone excess, or appear clinically non-functioning without hormonal symptoms. PETs occur sporadically, in association with the multiple endocrine neoplasia type 1 (MEN1) syndrome, or rarely the von Hippel-Lindau syndrome. READ MORE

  4. 2. The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis

    Author : Minna Thullberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor protein p16INK4a and its family members p15INK4b, p18INK4c and p19INK4d (the INK4 proteins) inhibit the cyclin-dependent kinases CDK4 and CDK6, which are key regulators of the retinoblastoma protein (pRb). pRb guars entry into the S phase of the mammalian cell division cycle (the cell cycle), a process evolved to ensure balanced cell proliferation. READ MORE

  5. 3. p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors

    Author : Jonas Fuxe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. READ MORE

  6. 4. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia

    Author : Aikaterini Barbouti; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fluorescent in situ hybridization; low-copy repeats; isochromosome 17q; MSI2 HOXA9; ETV6 ABL1; BCR ABL1; chronic myeloid leukemia; blast crisis; molecular genetics; Clinical genetics; Klinisk genetik;

    Abstract : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. READ MORE

  7. 5. Versatile and Antique World of RNA : The Simplicity of RNA Mediated Catalysis

    Author : Ema Kikovska; Leif Kirsebom; Venkat Gopalan; Uppsala universitet; []
    Keywords : Microbiology; RNA Catalysis; RNase P; Metal ions; tRNA Processing; Ribozyme; Mikrobiologi;

    Abstract : RNA is the only biological molecule that can function both as a repository of information and as a catalyst. This, together with the ability to self-replicate, led to recognition of RNA as ‘prelude to life’.My work highlights some of the important features of RNA as a catalyst, exemplified by RNase P. READ MORE