Search for dissertations about: "p24"

Showing result 1 - 5 of 28 swedish dissertations containing the word p24.

  2. 1. Plant-produced STI vaccine antigens with special emphasis on HIV-1 p24

    Author : Ingrid Lindh; Åke Strid; Sören Andersson; Edward Rybicki; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant-based vaccines; Arabidopsis thaliana; HIV-1; p24; GALT; mucosal immunity; Chlamydia trachomatis; MOMP; Daucus carota; Chemistry; Kemi; Chemistry; Kemi;

    Abstract : Objective: To establish stable transgenic non-toxic plants as a platform for plant-based vaccine production as well as potential oral delivery system of vaccine antigens for sexually transmitted infections (STIs). The concept is to immunize the mucosal immune system present in the gut-associated lymphoid tissues (GALT). READ MORE

  4. 2. Capacitive Biosensor - A Tool for Ultrasensitive Analysis : Application in Clinical Analysis and Process Monitoring

    Author : Kosin Teeparuksapun; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Capacitive Biosensor; Ultrasensitive Analysis; Clinical Analysis; Bioprocess Monitoring; Human Serum Albumin; HIV-1 p24; Host Cell Proteins; Protein A; Current Pulse;

    Abstract : Increasing demands for highly sensitive, accurate, fast and portable analytical assays have led to the development of new analytical tools. The integration of highly specific biological sensing elements and appropriate transducers has enabled design of even more efficient biosensor devices for the detection of target substances. READ MORE

  5. 3. Development of transgenic Arabidopsis thaliana and Daucus carota plant producing the p24 capsid protein from HIV-1 subtype C for the use as an edible plant-based vaccine model

    Author : Ingrid Lindh; Åke Strid; Elin Grahn; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; NATURAL SCIENCES; NATURVETENSKAP; Chemistry; Kemi; biokemi; Biochemistry;

    Abstract : .... READ MORE

  6. 4. The effect of alpha-HGA on HIV-1 replication

    Author : Masoud Youssefi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; p24; capsid formation; alpha-HGA; antiretroviral; uptake;

    Abstract : Different classes of anti HIV-1 drugs are now available for treatment of HIV-1 infection. Although improved, these drugs show adverse effects and their long-term efficiency is severely hampered by the emergence of resistant viruses. Therefore, less toxic and more effective anti HIV-1 therapeutics agents are still needed. READ MORE

  7. 5. Studies on HIV-1 core assembly

    Author : Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

    Abstract : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. READ MORE