Search for dissertations about: "p300"

Showing result 11 - 15 of 27 swedish dissertations containing the word p300.

  2. 11. Epigenetic Mapping in Type 2 Diabetes. Glucose-triggered histone modifications in various tissues

    Author : Bompada Pradeep; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; epigenetics; histone modifications; genome editing; ChIP-seq; RNA-seq; pancreatic islets; diabetic kidney disease; peripheral blood mononuclear cells; atherosclerosis;

    Abstract : Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. READ MORE

  4. 12. Notch signaling : from receptor cleavage to chromatin remodeling

    Author : Kia Strömberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : One of the principal signaling mechanisms that control development of multicellular organisms is the Notch signaling pathway. The transmembrane Notch receptor, presented at the cell surface, interacts with ligand on neighbouring cells. READ MORE

  5. 13. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

    Author : Maria Simonsson; Johan Ericsson; Eva Grönroos; Marikki Laiho; Uppsala universitet; []
    Keywords : Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

    Abstract : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. READ MORE

  6. 14. Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members

    Author : Daniel Wetterskog; Göteborgs universitet; []
    Keywords : ;

    Abstract : Aims: The platelet-derived growth factor ?-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. READ MORE

  7. 15. Transcription regulation across levels of chromatin organization

    Author : Roshan Vaid; Mattias Mannervik; Goncalo Castelo-Branco; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription; chromatin; epigenetics; Drosophila; embryo development; molekylär biovetenskap; Molecular Bioscience;

    Abstract : With advancements in high-throughput sequencing and high-resolution microscopy techniques, the significance of genome organization in transcription regulation is rapidly unveiling. Nonetheless, we are yet far from completely understanding this key relationship. READ MORE