Search for dissertations about: "p38 MAPK"

Showing result 16 - 20 of 79 swedish dissertations containing the words p38 MAPK.

  2. 16. Molecular basis for the anti-inflammatory properties of chlomethiazole

    Author : Anastasia Simi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Stroke; neuroprotection; p38 MAP kinase; chlomethiazole; interleukin-1; c-fos; inflammation; glia; lipopolysaccharide; molecular mechanisms; ischaemia;

    Abstract : Chlomethiazole (CMZ) exerts neuroprotective effects in animal models of stroke, and its clinical efficacy is currently evaluated in acute stroke patients. CMZ also protects the liver from alcohol- induced oxidative damage by inhibiting the cytochrome P450 2E1 (CYP2E1), as well as inflammation associated with alcohol liver disease (ALD) by inhibiting cytokine expression. READ MORE

  4. 17. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise

    Author : Jeffrey W Ryder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; glucose transport; GLUT4; hypoxia; exercise; Type II diabetes; MAPK; PPAR[gamma] thiazolidinediones;

    Abstract : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. READ MORE

  5. 18. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

    Author : Mei Yu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

    Abstract : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. READ MORE

  6. 19. Kinase cascades in the regulation of glucose homeostasis

    Author : Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Abstract : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. READ MORE

  7. 20. Changes in mitogen-activated protein kinase phosphorylation and inorganic phosphate induced by skeletal muscle contraction

    Author : Charlott Wretman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; MAP kinase; signal transduction; contraction; acute exercise; exercise intensity; fibre-type; concentric; ROS; eccentric.;

    Abstract : Skeletal muscles adjust to the level of contractile activity by different biochemical alterations. Contraction is a multifactorial stimulus with short-term metabolic effects and long-term responses due to changes in protein synthesis. READ MORE