Search for dissertations about: "p38 mitogen-activated protein kinases"

Showing result 1 - 5 of 19 swedish dissertations containing the words p38 mitogen-activated protein kinases.

  1. 1. Adenosine receptor signaling and the activation of mitogen-activated protein kinases

    Author : Gunnar Schulte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular adenosine levels with increased energy consumption. Adenosine is metabolized by adenosine deaminase and adenosine kinase. READ MORE

  2. 2. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

    Author : Karin Gewert; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. READ MORE

  3. 3. Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle

    Author : Ulrika Widegren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; MAP kinase; contraction; acute exercise; Akt kinase; exercise intensity; signal transduction; fiber-type;

    Abstract : Exercise-induced adaptations in skeletal muscle are regulated by numerous signaling mechanisms. However, little is known about the molecular signaling mechanisms linking muscle contraction or other exercise-associated stimuli to intracellular responses in skeletal muscle. READ MORE

  4. 4. Changes in mitogen-activated protein kinase phosphorylation and inorganic phosphate induced by skeletal muscle contraction

    Author : Charlott Wretman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; MAP kinase; signal transduction; contraction; acute exercise; exercise intensity; fibre-type; concentric; ROS; eccentric.;

    Abstract : Skeletal muscles adjust to the level of contractile activity by different biochemical alterations. Contraction is a multifactorial stimulus with short-term metabolic effects and long-term responses due to changes in protein synthesis. READ MORE

  5. 5. Signalling to Activation of Cytosolic Phospholipase A2 and Arachidonate Release in Macrophages

    Author : Gösta Hiller; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; signal transduction; dexamethasone; macrophages; phospholipase C; phosphatidylinositol 3-kinase; mitogen-activated protein kinases; cytosolic phospholipase A2; arachidonic acid; Histology; cytochemistry; histokemi; cytokemi; tissue culture; Histologi; vävnadskultur; histochemistry;

    Abstract : Eicosanoids include prostaglandins, thromboxanes and leukotrienes, which are arachidonic acid oxygenation products. These lipids make important contributions to the signs and symptoms of inflammatory diseases. READ MORE