Search for dissertations about: "p38 mitogen-activated protein kinases"

Showing result 11 - 15 of 19 swedish dissertations containing the words p38 mitogen-activated protein kinases.

  2. 11. Regulation and Function of MAP Kinases in PDGF Signaling

    Author : Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. READ MORE

  4. 12. Interleukin-17 in non-allergic airway inflammation

    Author : Martti Laan; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-17; airway inflammation; bronchial epithelial cells; neutrophils; T-lymphocytes; IL-8; IL-6; MAP kinases.;

    Abstract : Chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchial asthma and cystic fibrosis are common clinical disorders all characterized by airway neutrophilia. By releasing proteolytic enzymes and free oxygen radicals, neutrophils can contribute to the main features of these diseases such as airway obstruction, hypersecretion and remodelling. READ MORE

  5. 13. Glucose, Palmitate and Apolipoprotein CIII-induced Effects on Insulin-Producing β-cells

    Author : E-ri Maria Sol; Peter Bergsten; Noel Morgan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Background and aims: Type 2 diabetes mellitus results from complex interplay between genetic predisposition and environmental factors that together promote impairment of insulin-producing β-cells. Elevated levels of glucose, fatty acid palmitate and apolipoprotein CIII (apoCIII) are implicated in this process. READ MORE

  6. 14. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

    Author : Dariush Mokhtari; Nils Welsh; Michael Welsh; Anders Tengholm; Shanta Persaud; Uppsala universitet; []
    Keywords : Cell biology; MEKK-1; JNK; human islets; β-cells; siRNA; apoptosis; cell death; MAPK; nitric oxide; cytokines; streptozotocin; c-Rel; NF-κB; Cellbiologi;

    Abstract : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. READ MORE

  7. 15. Cellular responses to the DNA damaging cytolethal distending toxin

    Author : Lina Guerra; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytolethal distending toxin (CDT) is a genotoxin, which belongs to a group of bacterial protein toxins called cyclomodulins. These are characterized by their interference with the eukaryotic cell cycle. CDT causes DNA damage, which induces cell cycle arrest and apoptosis. READ MORE