Search for dissertations about: "p38-MAPK"

Showing result 1 - 5 of 61 swedish dissertations containing the word p38-MAPK.

  1. 1. p38 MAPK Signalling in Endothelial Apoptosis

    University dissertation from Department of Laboratory Medicine, Lund University

    Author : Simone Grethe; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

    Abstract : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. READ MORE

  2. 2. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

    Abstract : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. READ MORE

  3. 3. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Edlund; Pontus Aspenström; Maréne Landström; Tommy Andersson; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-beta; cytoskeleton; GTPases; mitogen-activated protein kinase kinase 3; TGF-beta-activated kinase 1; Apoptosis; Smad7; beta-catenin; p38 MAPK; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. READ MORE

  4. 4. Role of MAP Kinases in the Life and Death of Beta-cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Natalia Makeeva; Nils Welsh; Godfried Roomans; Thomas Mandrup-Poulsen; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; beta-cell; p38 MAPK; nitric oxide; apoptosis; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi;

    Abstract : The development of diabetes mellitus depends on the balance between beta-cell proliferation and death. As mitogen-activated protein kinases (MAPK) may control this balance, the aim of this study was to investigate the events leading to MAPK activation in beta-cells and the consequences of these events. READ MORE

  5. 5. Microbial and maternal influences on allergic sensitization during childhood: defining a role for monocytes

    University dissertation from Stockholm : The Wenner-Gren Institute, Stockholm University

    Author : Shanie Saghafian Hedengren; Eva Sverremark-Ekström; Susan Prescott; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Monocytes; allergic sensitization; maternal allergy; Toll-like receptor; p38-MAPK; IL-6; Epstein-Barr virus; early-life microbial exposure; NK cells; IFN-γ; MEDICINE Microbiology; immunology; infectious diseases Immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi; immunologi; Immunology;

    Abstract : Allergic diseases are influenced by genetics and the environment. Maternal allergy appears to confer a higher risk for allergic sensitization than paternal allergy, suggesting an in utero influence. READ MORE