Search for dissertations about: "p38-MAPK"
Showing result 6 - 10 of 63 swedish dissertations containing the word p38-MAPK.
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6. Regulation of neutrophil apoptosis
Abstract : The human neutrophil is the most abundant granulocyte and the major type of cell involved in an acute inflammatory response. Neutrophils are armed with various systems of enzymes, that can find and kill pathogens, but unfortunately, these "weapons" cannot distinguish between the host tissues and the "invaders. READ MORE
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7. Inhibition of WNT5A Signaling and Function in Malignant Melanoma
Abstract : The life-threatening disease of malignant melanoma is one of the fastest growing forms of cancer, affecting an estimated number of 200,000 patients worldwide every year. Although highly curable if detected early, once the melanoma has metastasized there are few treatment options and a median survival rate of only 6-9 months. READ MORE
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8. Molecular basis for the anti-inflammatory properties of chlomethiazole
Abstract : Chlomethiazole (CMZ) exerts neuroprotective effects in animal models of stroke, and its clinical efficacy is currently evaluated in acute stroke patients. CMZ also protects the liver from alcohol- induced oxidative damage by inhibiting the cytochrome P450 2E1 (CYP2E1), as well as inflammation associated with alcohol liver disease (ALD) by inhibiting cytokine expression. READ MORE
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9. 2-ME-Induced Apoptotic Signalling in Prostate Cancer PC3 Cells
Abstract : Prostate cancer is common in the Western society and current treatments are often associated with side effects, therefore improved therapeutic strategies are desired. 2-methoxyestradiol (2-ME), an endogenous metabolite of estradiol-17β inhibits tumor growth in vivo as it prevents angiogenesis. 2-ME has also direct cytotoxic effects on tumor cells. READ MORE
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10. On Neutrophil and Platelet Adhesive Interactions in Septic Lung Injury
Abstract : Sepsis induced by intestinal perforation is a life-threatening illness and is a frequent cause of leukocyte-mediated lung injury. Although antimicrobial therapy has been the central clinical strategy for these patients, the survival rates in such patients are still very low because of their impaired host defense mechanisms. READ MORE