Search for dissertations about: "p38"

Showing result 6 - 10 of 133 swedish dissertations containing the word p38.

  2. 6. Signal Transduction in Mast Cell Migration

    Author : Magnus Sundström; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; HMC-1; Kit; MAP kinase; mast cells; mastocytosis; p38; SCF; TGF-β; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Mast cells are essential effector cells in the immune system as they release several inflammatory mediators. An accumulation of mast cells has been described in inflammatory conditions such as asthma and allergic rhinitis. READ MORE

  4. 7. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Author : Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE

  5. 8. Inflammatory responses of gingival fibroblasts in the interaction with the periodontal pathogen Porphyromonas gingivalis

    Author : Eleonor Palm; Torbjörn Bengtsson; Hazem Khalaf; Gunnel Svensäter; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Porphyromonas gingivalis; fibroblasts; CXCL8; TGF-β1; IL-6; SLPI; IDO; c-JUN; PKC; p38; periodontitis; Biomedicin; Biomedicine;

    Abstract : .... READ MORE

  6. 9. Role of MAP Kinases in the Life and Death of Beta-cells

    Author : Natalia Makeeva; Nils Welsh; Godfried Roomans; Thomas Mandrup-Poulsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; beta-cell; p38 MAPK; nitric oxide; apoptosis; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : The development of diabetes mellitus depends on the balance between beta-cell proliferation and death. As mitogen-activated protein kinases (MAPK) may control this balance, the aim of this study was to investigate the events leading to MAPK activation in beta-cells and the consequences of these events. READ MORE

  7. 10. Regulation of neutrophil apoptosis

    Author : Maria Alvarado-Kristensson; Malmö Molekylär patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PP2A; p38 MAPK; caspases; signal transduction; inflammation; Apoptosis; human neutrophils;

    Abstract : The human neutrophil is the most abundant granulocyte and the major type of cell involved in an acute inflammatory response. Neutrophils are armed with various systems of enzymes, that can find and kill pathogens, but unfortunately, these "weapons" cannot distinguish between the host tissues and the "invaders. READ MORE