Search for dissertations about: "p53 and p21WAF1 expression"
Showing result 1 - 5 of 7 swedish dissertations containing the words p53 and p21WAF1 expression.
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1. DNA repair and the p53 pathway in ischemic and traumatic brain injury
Abstract : Ischemic and traumatic brain damage are major causes of disability and death. While much effort has been spent to develop pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. READ MORE
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2. Mechanisms of Regulation of the Cell Cycle Inhibitor p21Waf1/Cip1 in TGF-β-Mediated Cell Growth Inhibition
Abstract : TGF-β is the founding member of a multifunctional family of cytokines that regulate many aspects of cell physiology, including cell growth, differentiation, motility and death and play important roles in many developmental and pathological processes. TGF-β signals by binding to a heterotetrameric complex of type I and type II serine/threonine kinase receptors. READ MORE
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3. p53 functional loss by mutation and p53 antagonizing proteins during tumor development
Abstract : p53 is the most common target for genetic alterations in human cancers. Inactivation of wild type p53 function by point mutation, deletion or complexing with antagonizing proteins such as MDM2 and DNA tumor viral oncoproteins, is frequently found in human and rodent tumors. READ MORE
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4. Ploidy, cell proliferation and apoptosis in lymphoid malignancies : methodological and clinical aspects
Abstract : The DNA aneuploidy and proliferative activity have been previously shown to carry a clinical significance in Iymphoid malignancies. However, the application of these parameters is complicated by methodological difficulties. READ MORE
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5. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary
Abstract : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. READ MORE