Search for dissertations about: "p53R2"

Found 3 swedish dissertations containing the word p53R2.

  2. 1. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

    Author : Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

    Abstract : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. READ MORE

  4. 2. Transcriptional regulation of mouse ribonucleotide reductase

    Author : Anna Elfving; Lars Thelander; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotide reductase; promoters; cell cycle; transcriptional regulation; primer extension; protein purification; EMSA; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Abstract : All living organisms are made of cells and they store their hereditary information in the form of double stranded DNA. In all organisms DNA replication and repair is essential for cell division and cell survival. These processes require deoxyribonucleotides (dNTPs), the building blocks of DNA. READ MORE

  5. 3. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers

    Author : Johanna Smeds; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CDKN2A; ARF; p53; cell cycle regulation; mutation; melanoma; esophageal squamous cell carcinoma;

    Abstract : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. READ MORE