Search for dissertations about: "p57Kip2"

Showing result 1 - 5 of 9 swedish dissertations containing the word p57Kip2.

  2. 1. p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation

    Author : Magnus Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : p57Kip2 ; g lucocorticoids; cell cycle; apoptosis; lung development; transcriptional regulation;

    Abstract : Glucocorticoids (GCs), are steroid hormones with several important physiological implications, of which some are connected with the ability of GCs to inhibit cell proliferation. Although GC treatment normally accumulates cells in the GI phase of the cell cycle, the mechanisms behind this phenomenon are not well understood. READ MORE

  4. 2. The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation

    Author : Pinelopi Vlachos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of relevance in tumorigenesis. READ MORE

  5. 3. On molecular mechanisms of neural differentiation and forebrain development

    Author : Erik Södersten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telencephalic development is an extraordinary complex process where neural structures of highly diverse cell compositions emerge as the result of multiple developmental strategies imposing tight regulation, balance and timing of gene expression. Embryonic telencephalic neural stem cells (NSCs) can form the major cell types found in the telencephalon, and are thus an excellent model for studying transcriptional control of lineage choice mechanisms in CNS development. READ MORE

  6. 4. Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons

    Author : Åsa Wallén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred to as orphan receptors. READ MORE

  7. 5. Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms

    Author : Lars-Göran Bladh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoid receptor; glucocorticoids; cross-talk; NF-kappaB; AP-1; cell cycle; cell proliferation;

    Abstract : The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional independent domains, the N-terminal domain containing a major transactivation region, the central DNA binding domain (DBD) and the C-terminal domain that binds the hormone/ligand. READ MORE