Search for dissertations about: "p70 S6 kinase"

Showing result 1 - 5 of 6 swedish dissertations containing the words p70 S6 kinase.

  2. 1. Cyclic Nucleotide Phosphodiesterase 3B: Regulation in rat adipocytes and 3T3-L1 cells

    Author : Tova Landström; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3T3-L1 TNF-alpha; adipocyte; insulin; p70S6 kinase; mitogen-activated protein kinase; protein kinase B; phosphatidylinositol-3 kinase; phosphodiesterase 3B; cAMP; lipolysis; phosphorylation; signal transduction; Biochemistry; Metabolism; Biokemi; metabolism;

    Abstract : Insulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. READ MORE

  4. 2. Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease

    Author : Wen-Lin An; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; p70 S6 kinase; tau; protein translation; accumulation; phosphorylation;

    Abstract : One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at serine/threonine (S/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. READ MORE

  5. 3. Regulation of energy balance in Caenorhabditis elegans 

    Author : Ming Sheng; Simon Tuck; Lars Nilsson; Carina Holmberg-Still; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; C.elegans; fat metabolism; S6 Kinase; FT-IR; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Abstract : Obesity is a medical condition in which excess body fat has been accumulated. It is most commonly caused by imbalance between energy intake and energy expenditure (lack of physical activity and lower metabolic rate, etc.). READ MORE

  6. 4. The control of growth and metabolism in Caenorhabditis elegans

    Author : Josefin Friberg; Simon Tuck; Cathy Savage-Dunn; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TGFβ; insulin; collagen; p70 S6K; metabolism; growth; dauer; Caenorhabditis elegans; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : The control of growth is a poorly understood aspect of animal development. This thesis focuses on body size regulation in Caenorhabditis elegans, and in particular, how worms grow to a certain size. In C. elegans, a key regulator of size is the TGFβ homologue DBL-1. READ MORE

  7. 5. Molecular studies of intra-oocyte phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility

    Author : Pradeep Reddy Dubbaka Venu; Kui Liu; Evelyn Telfer; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primordial follicles; Oocyte; PI3K; Biochemistry; Biokemi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The primordial follicle pool is the main source of developing follicles in the ovary. The length of reproductive life and the onset of menopause are governed by the amount of primordial follicles in the ovary. READ MORE