Search for dissertations about: "p97"
Found 4 swedish dissertations containing the word p97.
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1. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation
Abstract : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. READ MORE
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2. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation
Abstract : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. READ MORE
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3. Regulation of HPV16 Early Gene Expression
Abstract : Human papillomavirus type 16 (HPV16) is the most common high-risk type and isassociated with more than 50% cervical cancer cases as well as a number of headand neck cancer cases. The life cycle of HPV16 is strictly linked to celldifferentiation in the squamous epithelium with expression of the HPV16 earlygenes. READ MORE
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4. Tipping the scales in cancer : novel mechanisms of inhibiting protein degradation
Abstract : Protein homeostasis (in short, ‘proteostasis’) requires the timely degradation of proteins to retain control on protein quality, amount and function. Two main proteolytic systems, the ubiquitin-proteasome system (UPS) and autophagy, complement each other to fulfill this regulatory role. READ MORE