Search for dissertations about: "paediatric patients drug use"

Showing result 1 - 5 of 8 swedish dissertations containing the words paediatric patients drug use.

2. 1. Drug treatment in children with focus on off-label drug use

   Author : Elin Kimland; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Child; drug treatment; off-label; drug related problems; adverse drug reactions; drug labelling;

   Abstract : There is a lack of paediatric documentation concerning efficacy and safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using different settings and design to evaluate pharmacological treatment in children, with focus on off-label drug use, is presented. READ MORE

4. 2. Safety of Medication in Paediatrics

   Author : Kristina Star; Karin Nordin; I Ralph Edwards; Richard Irvin Cook; Uppsala universitet; []
   Keywords : paediatrics; adverse drug reaction; drug-related problem; medication error; patient safety; individual case safety reports; pharmacovigilance; medication; nurses; health care personnel; dosage form; NSAID; dosing; prescription; antipsychotic medicines; postmarketing surveillance; Medicinsk vetenskap; Medical Science;

   Abstract : Background: In paediatrics, the limited documentation to guide medication, the lack of suitable dosage forms, and the continuous development in childhood present a scenario where safety of medication is a particular challenge.Aim: To explore reported adverse drug reactions (ADRs) and the challenges in prescribing and administering medicines in paediatrics, in order to identify and suggest areas needing international surveillance within medication safety and improvement in the clinical setting. READ MORE

5. 3. Manipulation of medicines, necessary in everyday practice for individualised doses in paediatric care

   Author : Åsa C. Andersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Introduction: Manipulation of medicines is often necessary in the paediatric setting due to lack of medicines suitable for paediatric patients. There are previous short-term frequency studies in different paediatric settings, but no long-term studies and no comparison between two different years in the same setting. READ MORE

6. 4. Responsible antibiotic use and diagnostic challenges in infectious diseases : studies in a resource-limited setting and a high-income setting

   Author : Anna Damlin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Antibiotic resistance is a globally emerging health challenge. In resource-limited settings, the burdens of infectious diseases and of antibiotic resistance are the highest. READ MORE

7. 5. Dose Adaptation Based on Pharmacometric Models

   Author : Johan Wallin; Mats Karlsson; Lena Friberg; Maria Garrido; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : Many drugs exhibit major variability in both pharmacokinetic (PK) and pharmacodynamic (PD) parameters that prevents the use of the same dose for all patients. Variability can occur both between patients (IIV) as well as within patients over the course of time (IOV). READ MORE