Search for dissertations about: "pancreatic β-cells"

Showing result 16 - 20 of 84 swedish dissertations containing the words pancreatic β-cells.

  1. 16. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hongyan Shuai; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

    Abstract : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. READ MORE

  2. 17. Studies of individual pancreatic -cells : Electrophysiological analysis of rhythmic behaviour and development of new techniques

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Staffan Dryselius; Uppsala universitet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic beta-cells; insulin release; signal transduction; cytoplasmic calcium; oscillations; patch clamp; ATP-regulated potassium channels; voltage-dependent calcium channels; metabolism; calcium ion; strontium ion; manganese ion; wavelets; de-noising; pattern recognition; superfusion; solution changes; microscopic labelling; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The insulin concentration in blood varies periodically, which is believed to prevent down-regulation of the hormone receptors. Loss of the regular insulin oscillations is considered to be an early sign of developing diabetes. READ MORE

  3. 18. Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells

    University dissertation from Department of Experimental Medical Science, Lund Univeristy

    Author : Celine Fernandez; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolomics; transcriptomics; treadmill; liver; HSL; cholesterol; proteomics;

    Abstract : Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. READ MORE

  4. 19. Short- and long-term effects of long-chain free fatty acids on pancreatic α- and β-cell function

    University dissertation from Charlotta Olofsson, BMC B11, Hs 66, Lund University

    Author : Charlotta Olofsson; Lunds universitet.; Lund University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetologi; sekretion; Endokrinologi; diabetology; secreting systems; Endocrinology; type-2 diabetes.; intracellular free Ca2 ; exocytosis; Free fatty acids; pancreatic α- and β-cells;

    Abstract : Popular Abstract in Swedish Kroppens blodglukoskoncentration regleras av celler i de Langerhanska öarna i bukspottkörteln. β (beta)-celler frisätter insulin då sockerhalten i blodet ökar, tex efter en måltid. READ MORE

  5. 20. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Geng Tian; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. READ MORE