Search for dissertations about: "parkinson’s disease"

Showing result 11 - 15 of 431 swedish dissertations containing the words parkinson’s disease.

  2. 11. Automating levodopa dosing schedules for Parkinson’s disease

    Author : Ilias Thomas; Jerker Westin; Moudud Alam; Björn Eskofier; Högskolan Dalarna; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexible Levodopa Optimizing Assistive Technology; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik;

    Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disease. Levodopa is mainly used to manage the motor symptoms of PD. However, disease progression and long-term use of levodopa cause reduced medication efficacy and side effects. When that happens, precise individualized dosing schedules are required. READ MORE

  4. 12. Studies on the Etiology of Parkinson's disease

    Author : Camilla Fardell; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease;

    Abstract : ABSTRACT Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the world and affects around 1% of the population over 60 years of age. The main symptoms of PD include bradykinesia, resting tremor and rigidity, caused to a large extent by degeneration of the dopaminergic neurons in substantia nigra. READ MORE

  5. 13. Intestinal transport of levodopa : Implications for the therapy of Parkinson's disease

    Author : Dag Nilsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa. duodenal Infusion; intestinal permeability; positron emission tomography; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Levodopa has been the basic treatment of patients with Parkinson's disease for the last 30 years. However, with time nearly all patients develop fluctuations in motor performance correlated to levodopa plasma concentrations. READ MORE

  6. 14. Pharmacotherapy for Parkinson's Disease - Observations and Innovations

    Author : Dag Nyholm; Sten-Magnus Aquilonius; Andrew Lees; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa; pharmacokinetics; infusion; drug delivery systems; electronic patient diary; Neurovetenskap; Neurology; Neurologi; Neurology; Neurologi;

    Abstract : Pharmacotherapy for Parkinson’s disease (PD) is based on levodopa, the most effective dopaminergic drug. The development of motor complications constitutes the major challenge for new or refined therapies. READ MORE

  7. 15. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders

    Author : Leire Almandoz Gil; Joakim Bergström; Martin Ingelsson; Kostas Vekrellis; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

    Abstract : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. READ MORE