Search for dissertations about: "patch clamp technique"

Showing result 1 - 5 of 35 swedish dissertations containing the words patch clamp technique.

  2. 1. Studies of individual pancreatic -cells : Electrophysiological analysis of rhythmic behaviour and development of new techniques

    Author : Staffan Dryselius; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic beta-cells; insulin release; signal transduction; cytoplasmic calcium; oscillations; patch clamp; ATP-regulated potassium channels; voltage-dependent calcium channels; metabolism; calcium ion; strontium ion; manganese ion; wavelets; de-noising; pattern recognition; superfusion; solution changes; microscopic labelling; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The insulin concentration in blood varies periodically, which is believed to prevent down-regulation of the hormone receptors. Loss of the regular insulin oscillations is considered to be an early sign of developing diabetes. READ MORE

  4. 2. Electrophysiology of pancreatic A-, B- and D-cells studied in intact mouse islets of Langerhans

    Author : Sven Göpel; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; somatostatin; glucagon; insulin; patch-clamp; membrane potential; Pancreatic islet; ion channel; diabetes; Physiology; Fysiologi;

    Abstract : Abstract The electrophysiological properties of insulin-secreting b-cells, glucagon-releasing a-cells and somatostation-producing d-cells in intact mouse pancreatic islets were investigated using the perforated patch whole-cell technique. It is demonstrated that it is possible to functionally identify the different cell types in situ. READ MORE

  5. 3. Patch-clamp studies of the GABAA receptor using microfluidic methods

    Author : Maria Millingen; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channel; microfluidics; GABAA receptor;

    Abstract : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. READ MORE

  6. 4. Thermo- and chemosensitive properties of Transient Receptor Potential Ankyrin 1 ion channels

    Author : Lavanya Moparthi; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TRP ion channels; TRPA1; ankyrin repeat domain; thermosensation; chemosensation; cold sensor; electrophiles; non-electrophiles; planar lipid bilayers; patch-clamp; fluorescence spectroscopy; mass spectrometry;

    Abstract : The ability to sense and accommodate to an ever-changing environment is crucial for the survival of living organisms. Transient Receptor Potential (TRP) ion channels comprise a large superfamily of cation conducting membrane proteins that function as molecular sensors in diverse sensory processes including perception of light, taste, smell, sound, touch and temperature. READ MORE

  7. 5. Bridging the gap in translational epilepsy research - A patient brain tissue platform for validating animal data

    Author : Jenny Wickham; Epilepsicentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; patch clamp technique; human tissue; Optogenetics; Dentate gyrus; Subiculum; Hippocampus; in vitro;

    Abstract : .... READ MORE