Search for dissertations about: "patient-derived xenograft"
Showing result 6 - 10 of 13 swedish dissertations containing the words patient-derived xenograft.
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6. Preclinical investigation of novel therapies against neuroblastoma
Abstract : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. READ MORE
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7. Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications
Abstract : Brain tumors are the most common solid tumors in children. Current treatment protocols fail in 25% of patients and are associated with significant long-term adverse effects in survivors. READ MORE
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8. Hypoxia and Stem Cells in Normal and Tumor Development
Abstract : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. READ MORE
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9. Development of Computational Methods for Cancer Research: Strategies for closing the feedback loop in omics workflows
Abstract : As the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. READ MORE
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10. New insights of LXR signalling in inhibition of cancer proliferation and inflammation
Abstract : Liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear receptor (NR) superfamily. Up-to-date, more than 1900 publications have established the role of LXRs in cholesterol homeostasis, lipogenesis, glucose metabolism, atherosclerosis, proliferation, and inflammation. READ MORE