Search for dissertations about: "pax6"
Showing result 11 - 15 of 19 swedish dissertations containing the word pax6.
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11. Maf transcription factors in beta cell function
Abstract : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. READ MORE
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12. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology
Abstract : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. READ MORE
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13. On GABAergic interneuron diversity and maturation
Abstract : GABAergic interneurons provide finely, distinct styles of inhibition granted by their unique targeting preferences, molecular profiles, and morphological silhouettes. A central quest of my thesis was to explore what constitutes such diversity, touching upon how this di- versity is reached and preserved during development and what maintains distinct functional features later on. READ MORE
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14. Optic nerve hypoplasia in children : prevalence, associated disorders and genetic causes
Abstract : Optic nerve hypoplasia (ONH) is a congenital ocular malformation with a thin optic nerve in one or both eyes. ONH has been associated with neurodevelopmental disorders and pituitary dysfunction, but the prevalence of these comorbidities are still unknown, especially in children with less severe visual impairment and unilateral disease. READ MORE
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15. Morphogen interpretation in the developing nervous system
Abstract : Development of the central nervous system relies on the generation of specialized cell types in a tightly controlled spatial and temporal order from neural progenitor cells. Morphogen molecules, secreted by defined sources, spatially organize neural progenitors by inducing discrete expression patterns of cell fate determinant genes in a concentration-dependent manner. READ MORE