Search for dissertations about: "pegylated"

Showing result 1 - 5 of 30 swedish dissertations containing the word pegylated.

2. 1. Effects of gangliosides and PEG-lipids on the structure, properties and interactions of lipid self-assemblies

   Author : Philipp Grad; Katarina Edwards; Marité Cárdenas; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lipid self-assemblies; solution-solid interface; liposomes; lipodisks; lipid bilayers; liposome permeability; cuvettes;

   Abstract : When developing or utilizing lipid-based nanocarriers detailed structural characterization of the lipid self-assemblies, as well as in depth knowledge and control of their interaction with solids materials, is necessary to understand the behaviour. Disregarding one of the parameters can lead to misinterpretation of the results due to non-uniform samples or experimental artifacts caused by undesirable interactions with solid surfaces. READ MORE

4. 2. Studying the influence of the physicochemical properties of lipid nanoparticles for mucosal vaccine delivery

   Author : Karin Norling; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; nanoparticles; CTA1-DD; liposomes; dendritic cells; lipodisks; antigen presentation; flow cytometry; vaccine carriers; TIRF microscopy;

   Abstract : Lipid-based nanoparticles have attracted attention as promising pharmaceutical carriers. Reports of them having inherent adjuvant properties make them particularly interesting as vaccine vectors; however, the physicochemical profile of an ideal nanoparticle for mucosal vaccine delivery remains unknown. READ MORE

5. 3. Pharmacometric models in the development of biological medicinal products

   Author : Ari Brekkan; Mats Karlsson; Siv Jönsson; Philip Lowe; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; model-based analysis; NONMEM; population modelling.;

   Abstract : Biological medicinal products (BMPs) are a successful class of drugs that are indicated in numerous diseases.  Common among them is that complexities associated with their manufacture and analysis lead to a high cost compared to small-molecular weight drugs. READ MORE

6. 4. Liposomes for mucosal vaccine delivery: physicochemical characterization and biological application

   Author : Karin Norling; Chalmers tekniska högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanoparticles; vaccine carriers; antigen presentation; dendritic cells; surface plasmon resonance; flow cytometry; liposomes; cellular uptake; fluorescence microscopy; influenza;

   Abstract : Liposomes are attractive vaccine carriers due to their potential to act as adjuvants, and to the fact that their composition and characteristics are virtually endlessly customizable. However, the precise physicochemical profile of an ideal carrier liposome for mucosal vaccines is still widely unknown, and how different properties affect key steps in the acquisition of protective immunity remains to be elucidated. READ MORE

7. 5. Clinical and Genetic studies in Chronic Myeloid Leukaemia

   Author : Hjalmar Flygt; Ulla Olsson Strömberg; Stina Söderlund; Lucia Cavelier; Jane Apperley; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Chronic Myeloid Leukemia; Medicinsk vetenskap; Medical Science;

   Abstract : This thesis explores strategies to enhance deep molecular response (DMR) rates and treatment-free remission (TFR) eligibility in chronic myeloid leukaemia (CML), investigates factors linked to treatment milestone failures, describes tyrosine kinase inhibitor (TKI) discontinuation outcomes in a population-based cohort, and examines TFR probabilities after a second TKI discontinuation. In paper I we examined data from the Swedish CML registry on 128 CML patients in chronic phase with a reported TKI discontinuation of ≥1 month due to DMR. READ MORE