Search for dissertations about: "peptide biosensors"

Showing result 1 - 5 of 6 swedish dissertations containing the words peptide biosensors.

  2. 1. Functionalization and characterization of surface supported lipid membranes and their application in cell culture

    Author : Dorota Thid; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cell - surface interaction; supported phospholipid bilayer; IKVAV; DHA; stem progenitor cells; neural cells; surface analytical techniques; QCM-D; surface functionalization; peptide; cell differentiation; cell attachment; membrane; fatty acid;

    Abstract : Phospholipid bilayers supported on a solid surface constitute a versatile, biomimetic platform for a variety of applications, such as biosensing, drug delivery research, cell engineering and as cell membrane mimics in fundamental cell research. Phosphocholine supported lipid bilayers are resistant to cell attachment in a wide range of conditions, and can be functionalized with bioactive signaling molecules to promote specific interactions with cells. READ MORE

  4. 2. C-peptide structural and functional relationships studied by biosensor technology and mass spectrometry

    Author : Ermias Melles; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Proinsulin C-peptide; biosensor; mass spectrometry;

    Abstract : Proinsulin C-peptide has a number of biological activities and receives interest focusing on the therapeutic potential as a candidate for future co-replacement therapy with insulin in type 1 diabetes. Based on conservation results from comparisons of 22 mammalian proinsulin variants, analogs were constructed for studies of phosphorylation of mitogenactivated protein kinases (MAPKs) in Swiss 3T3 fibroblasts. READ MORE

  5. 3. Structure analysis and molecular recognition studies of bio-functionalized surfaces

    Author : Cecilia Vahlberg; Kajsa Uvdal; Carla Puglia; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : Biological and chemical reactions involved in physiological processes are often complex and very sophisticated. Such processes can be mimicked in the laboratory to obtain important knowledge, valuable for the  development of new diagnostic methods, drugs and biosensors. READ MORE

  6. 4. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    Author : Geng Tian; Erik Gylfe; Anders Tengholm; Patrick Gilon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. READ MORE

  7. 5. A Biotechnology Perspective on Silicon Nanowire FETs for Biosensor Applications

    Author : Nima Jokilaakso; Amelie Eriksson Karlström; Christer Wingren; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : The study of silicon nanowire-FET-based electronic biosensor applications is an emerging scientific field. These biosensors have the benefit of being theoretically extremely sensitive and reports of down to femtomolar (fM) levels of biomolecule detection have been reported. READ MORE