Search for dissertations about: "peptide fragmentation"

Showing result 11 - 15 of 29 swedish dissertations containing the words peptide fragmentation.

  2. 11. Derivatisation of peptides for collision-induced dissociation mass spectrometry

    Author : Ingemar Lindh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This study is concerned with the mass spectrometric analysis of peptides C-terminally derivatised with aminosulphonic acids. The aim was to increase the sensitivity of detection and to simplify the fragmentation patterns obtained upon collision-induced dissociation. READ MORE

  4. 12. High Rate Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Author : Youri Tsybin; Per Håkansson; Ron M.A. Heeren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; mass spectrometry; Fourier transform ion cyclotron resonance; peptides and proteins; ion-electron interaction; electron capture dissociation; infrared multiphoton dissociation; liquid chromatography; capillary electrophoresis; Fysik; Physics; Fysik;

    Abstract : Advances in science and technology during the past decade have greatly enhanced the level of the structural investigation of macromolecules – peptides and proteins. Biological mass spectrometry has become one of the most precise and sensitive techniques in peptide and protein analysis. READ MORE

  5. 13. Chemical labelling methods for gel free based proteomics

    Author : Åsa Wåhlander; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biotechnology; Bioteknik; Biokemisk teknik; Biochemical technology; 2D-HPLC; isotopes; labelling; proteomics; mass spectrometry;

    Abstract : In this thesis different aspects of gel free procedures for mass spectrometry based proteome analysis are addressed, with emphasis on labelling techniques. It is based on three original articles where the effects imposed onto peptides upon modification are investigated, and the development of a new type of labelling strategy is described. READ MORE

  6. 14. Advancing bioinformatics methods for in-depth proteome analysis based on high-resolution mass spectrometry

    Author : Bo Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mass spectrometry-based shotgun proteomics has become one of the essential techniques for comprehensive studies of living systems. Due to the inherent complexity of proteomes and the data, bioinformatics plays a critical role to translate mass spectra into biological information and knowledge. READ MORE

  7. 15. Regulation of apoptosis in the thyroid epithelium

    Author : Abeba Demelash; Göteborgs universitet; []
    Keywords : Thyroid; Apoptosis; Caspase; Calpain; Hydrogen peroxide; TGF-beta; Staurosporine; Selenium; Cytochrome c;

    Abstract : Apoptosis or programmed cell death allows the multicellular organism to remove cells that are in excess or potentially dangerous. Apoptosis has to be strictly controlled, yet inappropriately activated or suppressed apoptototic may contribute to a variety of diseases, including cancer, autoimmune disorders and neurodegenerative conditions. READ MORE